Persistent impairment on spirometry in chronic eosinophilic pneumonia: A longitudinal observation study (Shizuoka-CEP study).
Background: Chronic eosinophilic pneumonia (CEP) is characterized by the accumulation of eosinophils in the lung with unknown etiology. Although systemic corticosteroid administration leads to dramatic improvement, nearly half the patients with CEP experience relapse and some develop persistent impa...
| Publicado en: | Annals of Allergy, Asthma & Immunology Vol. 119; no. 5; pp. 422 - 423 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Nov2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126230676&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126230676 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10811206 1FN jtl: Annals of Allergy, Asthma & Immunology issn: 10811206 maglogo: N pubinfo: dt: Nov2017 vid: 119 iid: 5 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 126230676 126230676 NLM28942952 126230676 10.1016/j.anai.2017.08.009 NLM28942952 126230676 ppf: 422 ppct: 1 formats: tig: atl: Persistent impairment on spirometry in chronic eosinophilic pneumonia: A longitudinal observation study (Shizuoka-CEP study). aug: au: Suzuki, Yuzo Oyama, Yoshiyuki Hozumi, Hironao Imokawa, Shiro Toyoshima, Mikio Yokomura, Koshi Nakamura, Hidenori Kuroishi, Shigeki Karayama, Masato Furuhashi, Kazuki Enomoto, Noriyuki Fujisawa, Tomoyuki Nakamura, Yutaro Inui, Naoki Koshimizu, Naoki Yamada, Takashi Mori, Kazutaka Masuda, Masafumi Shirai, Toshihiro Hayakawa, Hiroshi affil: Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan sug: subj: Lung Physiology Eosinophils Immunology Pulmonary Eosinophilia Diagnosis Asthma Epidemiology Glucocorticoids Therapeutic Use Pulmonary Eosinophilia Epidemiology Adult Male Female Spirometry Middle Age Pulmonary Eosinophilia Drug Therapy Prospective Studies Chronic Disease Aged, 80 and Over Aged Young Adult Prognosis Comorbidity Recurrence Prednisolone Therapeutic Use Japan Human Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adult: 19-44 years Middle Aged: 45-64 years Aged, 80 & over Aged: 65+ years Male Female ab: Background: Chronic eosinophilic pneumonia (CEP) is characterized by the accumulation of eosinophils in the lung with unknown etiology. Although systemic corticosteroid administration leads to dramatic improvement, nearly half the patients with CEP experience relapse and some develop persistent impairment of pulmonary function. However, predictive factors for this persistent impairment have not been determined.Objective: To investigate the occurrence of persistent impairment of pulmonary function in CEP and determine its predictive factors.Methods: This observational study consisted of 133 consecutive patients with CEP who were followed for longer than 1 year. Spirometry was performed at the time of diagnosis and at follow-up.Results: During the observational period (6.1 ± 4.1 years), relapse occurred in 75 patients (56.4%). Remarkably, 42 patients (31.6%) had a persistent pulmonary function defect (27 obstructive, 10 restrictive, and 4 obstructive and restrictive cases) at the last evaluation. Logistic analyses showed that the relapse was associated with neither persistent obstructive nor restrictive defects. Persistent obstructive defect was significantly associated with the comorbidity of asthma and obstructive defect at the initial CEP diagnosis, whereas persistent restrictive defect was significantly related to reticulation at high-resolution computer tomography and restrictive defect at diagnosis.Conclusion: Persistent impairment of pulmonary function is common in CEP. Concurrent asthma and obstructive defects at diagnosis were predictors for persistent obstructive impairments, whereas reticulation at high-resolution computer tomography and restrictive defect at diagnosis predicted persistent restrictive impairment. Attention should be paid to these persistent impairments in the management of CEP.Trial Registration: http://www.umin.ac.jp/ctr/index-j.htm Identifier: UMIN000019092 (principal investigator, Takafumi Suda, MD, PhD). pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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