Assessment of liver fibrosis in chronic hepatitis: comparison of shear wave elastography and transient elastography.
Purpose: To evaluate the diagnostic accuracy of shear wave elastography (SWE) and transient elastography (TE) in the evaluation of liver fibrosis in chronic hepatitis B (CHB) and C (CHC) patients taking liver biopsy as gold standard. Methods: Ethics committee approved this prospective cross-sectiona...
| Publicado en: | Abdominal Radiology Vol. 42; no. 12; pp. 2864 - 2874 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126318316&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126318316 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Dec2017 vid: 42 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126318316 144156624 10.1007/s00261-017-1213-5 126318316 ppf: 2864 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Assessment of liver fibrosis in chronic hepatitis: comparison of shear wave elastography and transient elastography. aug: au: Paul, Shashi Das, Prasenjit Mahanta, Mousumi Sreenivas, Vishnubhatla Kedia, Saurabh Kalra, Nancy Kaur, Harpreet Vijayvargiya, Maneesh Ghosh, Shouriyo Gamanagatti, Shivanand Shalimar Gupta, Siddhartha Acharya, Subrat affil: Department of Radiodiagnosis , All India Institute of Medical Sciences , New Delhi 110029 India sug: ab: Purpose: To evaluate the diagnostic accuracy of shear wave elastography (SWE) and transient elastography (TE) in the evaluation of liver fibrosis in chronic hepatitis B (CHB) and C (CHC) patients taking liver biopsy as gold standard. Methods: Ethics committee approved this prospective cross-sectional study. Between October 2012 and December 2014, consecutive CHB/CHC patients fulfilling the inclusion criteria were included-age more than 18 years, informed written consent, willing and suitable for liver biopsy. SWE, TE, and biopsy were performed the same day. Liver stiffness measurement (LSM) cut-offs for various stages of fibrosis were generated for SWE and TE. AUC, sensitivity, specificity, and positive/negative predictive values were estimated individually or in combination. Results: CH patients ( n = 240, CHB 172, CHC 68), 176 males, 64 females, mean age 32.6 ± 11.6 years were enrolled. Mean LSM of patients with no histological fibrosis (F0) was 5.0 ± 0.7 and 5.1+1.4 kPa on SWE and TE, respectively. For differentiating F2 and F3-4 fibrosis on SWE, at 7.0 kPa cut-off, the sensitivity was 81.3% and specificity 77.6%. For TE, at 8.3 kPa cut-off, sensitivity was 81.8% and specificity 83.1%. For F3 vs. F4, SWE sensitivity was 83.3% and specificity 90.7%. At 14.8 kPa cut-off, TE showed similar sensitivity (83.3%) but specificity increased to 96.5%. Significant correlation between SWE and TE was observed ( r = 0.33, p < 0.001). On combining SWE and TE, a drop in sensitivity with increased specificity for all stages of liver fibrosis occured. Conclusion: SWE is an accurate technique for evaluating liver fibrosis. SWE compares favorably with TE especially for predicting advanced fibrosis/cirrhosis. Combining SWE and TE further improves specificity. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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