Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into Ca2+ (mis)handling.
Excitation--contraction coupling in cardiac myocytes requires calcium influx through L-type calcium channels in the sarcolemma, which gates calcium release through sarcoplasmic reticulum ryanodine receptors in a process known as calcium-induced calcium release, producing a myoplasmic calcium transie...
| Publicado en: | Clinical Medicine Insights: Cardiology Vol. 11; pp. 1 - 12 |
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| Autores principales: | , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126387431&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126387431 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11795468 B3KL jtl: Clinical Medicine Insights: Cardiology issn: 11795468 maglogo: Y pubinfo: dt: 2017 vid: 11 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 126387431 126387431 126387431 10.1177/1179546817698602 126387431 ppf: 1 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into Ca2+ (mis)handling. aug: au: Maleckar, Mary M. Edwards, Andrew G. Louch, William E. Lines, Glenn T. affil: Simula Research Laboratory, Center for Cardiological Innovation and Center for Biomedical Computing, Lysaker, Norway sug: subj: Cardiovascular System Physiology Electrophysiology Myocytes, Cardiac Physiopathology Calcium Physiology Calcium Metabolism Models, Structural Models, Biological Computer Simulation ab: Excitation--contraction coupling in cardiac myocytes requires calcium influx through L-type calcium channels in the sarcolemma, which gates calcium release through sarcoplasmic reticulum ryanodine receptors in a process known as calcium-induced calcium release, producing a myoplasmic calcium transient and enabling cardiomyocyte contraction. The spatio-temporal dynamics of calcium release, buffering, and reuptake into the sarcoplasmic reticulum play a central role in excitation--contraction coupling in both normal and diseased cardiac myocytes. However, further quantitative understanding of these cells' calcium machinery and the study of mechanisms that underlie both normal cardiac function and calcium-dependent etiologies in heart disease requires accurate knowledge of cardiac ultrastructure, protein distribution and subcellular function. As current imaging techniques are limited in spatial resolution, limiting insight into changes in calcium handling, computational models of excitation--contraction coupling have been increasingly employed to probe these structure--function relationships. This review will focus on the development of structural models of cardiac calcium dynamics at the subcellular level, orienting the reader broadly towards the development of models of subcellular calcium handling in cardiomyocytes. Specific focus will be given to progress in recent years in terms of multi-scale modeling employing resolved spatial models of subcellular calcium machinery. A review of the state-of-the-art will be followed by a review of emergent insights into calcium-dependent etiologies in heart disease and, finally, we will offer a perspective on future directions for related computational modeling and simulation efforts. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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