The GABAergic system in prefrontal cortex and hippocampus modulates context-related extinction learning and renewal in humans.
Context-related extinction learning and renewal in humans is mediated by hippocampal and prefrontal regions. Renewal is defined as the reoccurrence of an extinguished response if the contexts present during extinction learning and recall differ. Animal studies implicate hippocampal γ-aminobutyric ac...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 6; pp. 1885 - 1901 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126486077&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126486077 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2017 vid: 11 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126486077 126486077 143949513 NLM27928709 126486077 10.1007/s11682-016-9662-y NLM27928709 126486077 ppf: 1885 ppct: 16 formats: fmt: @attributes: type: P tig: atl: The GABAergic system in prefrontal cortex and hippocampus modulates context-related extinction learning and renewal in humans. aug: au: Lissek, Silke Golisch, Anne Glaubitz, Benjamin Tegenthoff, Martin affil: Department of Neurology , BG University Hospital Bergmannsheil, Ruhr-University Bochum , Bochum Germany sug: subj: Receptors, Cell Surface Metabolism Frontal Lobe Metabolism Reinforcement (Psychology) Hippocampus Metabolism Young Adult Memory Drug Effects Reaction Time GABA Agonists Pharmacodynamics Lorazepam Pharmacodynamics Brain Mapping Visual Perception Drug Effects Neuropsychological Tests Hippocampus Drug Effects Magnetic Resonance Imaging Male Hippocampus GABA Metabolism Visual Perception Physiology Frontal Lobe Adult Female Memory Frontal Lobe Drug Effects Reinforcement (Psychology) Drug Effects Human Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Adult: 19-44 years Male Female ab: Context-related extinction learning and renewal in humans is mediated by hippocampal and prefrontal regions. Renewal is defined as the reoccurrence of an extinguished response if the contexts present during extinction learning and recall differ. Animal studies implicate hippocampal γ-aminobutyric acid (GABA) A receptors in extinction and renewal. However, human studies on GABAergic mechanisms in extinction learning are lacking. In this fMRI study, we therefore investigated the role of the GABAergic system in context-related extinction learning and renewal. Participants treated with the GABA A agonist lorazepam prior to extinction learning were impaired in encoding changed associations during extinction learning, regardless of context, and in retrieving extinction associations during recall. In contrast, retrieval of associations learned during acquisition was largely unaffected, which led to reduced genuine renewal, since acquisition associations were retrieved context-independently. These deficits, which were presumably due to weak encoding of extinction associations, were related to altered BOLD activation in regions relevant for context processing and retrieval, as well as response selection: reduced activation in bilateral PFC and hippocampus during extinction learning and recall, and increased ventromedial/orbitofrontal cortex activation during recall. Our findings indicate that the GABergic system is involved in context-related extinction learning and recall in humans, by modulating hippocampus-based context processing and PFC-based processing of changed associations and subsequent response selection. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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