Neural correlates of correct and failed response inhibition in heavy versus light social drinkers: an fMRI study during a go/no-go task by healthy participants.
The ability to suppress responses that are inappropriate, as well as the mechanisms monitoring the accuracy of actions in order to compensate for errors, is central to human behavior. Neural alterations that prevent stopping an inaccurate response, combined with a decreased ability of error monitori...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 6; pp. 1796 - 1812 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126486084&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126486084 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2017 vid: 11 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126486084 126486084 144057573 NLM27832450 126486084 10.1007/s11682-016-9654-y NLM27832450 126486084 ppf: 1796 ppct: 16 formats: fmt: @attributes: type: P tig: atl: Neural correlates of correct and failed response inhibition in heavy versus light social drinkers: an fMRI study during a go/no-go task by healthy participants. aug: au: Campanella, Salvatore Absil, Julie Carbia Sinde, Carina Schroder, Elisa Peigneux, Philippe Bourguignon, Mathieu Petieau, Mathieu Metens, Thierry Nouali, Mustapha Goldman, Serge Cheron, Guy Verbanck, Paul De Tiège, Xavier De Tiège, Xavier affil: Laboratoire de Psychologie Médicale et d'Addiction, ULB Neuroscience Institute (UNI) , Université Libre de Bruxelles (ULB) , Place Vangehuchten B-1020 Brussels Belgium sug: subj: Behavior Brain Physiology Alcohol Drinking Brain Physiopathology Motor Activity Physiology Adult Alcohol-Related Disorders Psychosocial Factors Magnetic Resonance Imaging Young Adult Male Neuropsychological Tests Brain Mapping Reaction Time Hand Physiology Female Brain Alcohol-Related Disorders Physiopathology Funding Source Human Adult: 19-44 years Male Female ab: The ability to suppress responses that are inappropriate, as well as the mechanisms monitoring the accuracy of actions in order to compensate for errors, is central to human behavior. Neural alterations that prevent stopping an inaccurate response, combined with a decreased ability of error monitoring, are considered to be prominent features of alcohol abuse. Moreover, (i) alterations of these processes have been reported in heavy social drinkers (i.e. young healthy individuals who do not yet exhibit a state of alcohol dependence); and (ii) through longitudinal studies, these alterations have been shown to underlie subsequent disinhibition that may lead to future alcohol use disorders. In the present functional magnetic resonance imaging study, using a contextual Go/No-Go task, we investigated whether different neural networks subtended correct inhibitions and monitoring mechanisms of failed inhibitory trials in light versus heavy social drinkers. We show that, although successful inhibition did not lead to significant changes, neural networks involved in error monitoring are different in light versus heavy drinkers. Thus, while light drinkers exhibited activations in their right inferior frontal, right middle cingulate and left superior temporal areas; heavy drinkers exhibited activations in their right cerebellum, left caudate nucleus, left superior occipital region, and left amygdala. These data are functionally interpreted as reflecting a "visually-driven emotional strategy" vs. an "executive-based" neural response to errors in heavy and light drinkers, respectively. Such a difference is interpreted as a key-factor that may subtend the transition from a controlled social heavy consumption to a state of clinical alcohol dependence. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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