Diametrical relationship between gray and white matter volumes in autism spectrum disorder and schizophrenia.
Autism spectrum disorders and schizophrenia have been variously characterized as separate nosological entities with overlapping deficits in social cognition or diametrical extremes of a phenotypic continuum. This study aimed to determine how these models apply to comparative morphometric data. MRI s...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 6; pp. 1823 - 1836 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126486089&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126486089 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2017 vid: 11 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126486089 126486089 143951366 NLM27882449 126486089 10.1007/s11682-016-9648-9 NLM27882449 126486089 ppf: 1823 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Diametrical relationship between gray and white matter volumes in autism spectrum disorder and schizophrenia. aug: au: Mitelman, Serge Bralet, Marie-Cecile Haznedar, M. Hollander, Eric Shihabuddin, Lina Hazlett, Erin Buchsbaum, Monte Mitelman, Serge A Haznedar, M Mehmet Hazlett, Erin A Buchsbaum, Monte S affil: Autism and Obsessive-Compulsive Spectrum Program, Anxiety and Depression Program, Department of Psychiatry and Behavioral Science , Albert Einstein College of Medicine and Montefiore Medical Center , Bronx 10467 USA sug: subj: Brain Gray Matter Schizophrenia Adult Brain Pathology Male Gray Matter Pathology Schizophrenia Pathology Body Weights and Measures Human Female Magnetic Resonance Imaging Image Processing, Computer Assisted Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Adult: 19-44 years Male Female ab: Autism spectrum disorders and schizophrenia have been variously characterized as separate nosological entities with overlapping deficits in social cognition or diametrical extremes of a phenotypic continuum. This study aimed to determine how these models apply to comparative morphometric data. MRI scans of the brain were obtained in 49 subjects with schizophrenia, 20 subjects with autism and 39 healthy controls. Images were parcellated into 40 Brodmann areas and entered into repeated-measures ANOVA for between-group comparison of global and localized gray and white matter volumes. A pattern of lower gray mater volumes and greater white matter volumes was found in subjects with schizophrenia in comparison to subjects with autism. For both gray and white matter, this pattern was most pronounced in regions associated with motor-premotor and anterior frontal cortex, anterior cingulate, fusiform, superior and middle temporal gyri. Patient groups tended to diverge from healthy controls in opposite directions, with greater-than-normal gray matter volumes and lower-than-normal white matter volumes in subjects with autism and reversed patterns in subjects with schizophrenia. White matter reductions in subjects with autism were seen in posterior frontal lobe and along the cingulate arch. Normal hemispheric asymmetry in the temporal lobe was effaced in subjects with autism and schizophrenia, especially in the latter. Nearly identical distribution of changes and diametrically divergent volumetry suggest that autism and schizophrenia may occupy opposite extremes of the same cognitive continuum. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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