Neuropsychiatric symptoms of cholinergic deficiency occur with degradation of the projections from the nucleus basalis of Meynert.
This study aims to evaluate the relation between a cluster of neuropsychiatric symptoms related to cholinergic deficiency and degradation of the cortical cholinergic projections which project from the nucleus basalis of Meynert to the cerebral cortex. An atlas of the pathway from the nucleus basalis...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 6; pp. 1707 - 1720 |
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| Autores principales: | , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126486099&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126486099 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2017 vid: 11 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126486099 126486099 144153306 NLM27787708 126486099 10.1007/s11682-016-9631-5 NLM27787708 126486099 ppf: 1707 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Neuropsychiatric symptoms of cholinergic deficiency occur with degradation of the projections from the nucleus basalis of Meynert. aug: au: Dalen, Jan Caan, Matthan Gool, Willem Richard, Edo van Dalen, Jan Willem Caan, Matthan W A van Gool, Willem A affil: Department of Neurology, Academic Medical Center , University of Amsterdam , Meibergdreef 9 1105 AZ Amsterdam Netherlands sug: subj: Neurodegenerative Diseases Basal Ganglia Neurons Pathology Dementia Aged Brain Pathology Aged, 80 and Over Cross Sectional Studies Cox Proportional Hazards Model Brain Linear Regression Dementia Pathology Atrophy Prospective Studies Neurodegenerative Diseases Mortality Neural Pathways Pathology Neural Pathways Neurodegenerative Diseases Pathology Male Magnetic Resonance Imaging Female Dementia Mortality Basal Ganglia Pathology Human Aged: 65+ years Aged, 80 & over Male Female ab: This study aims to evaluate the relation between a cluster of neuropsychiatric symptoms related to cholinergic deficiency and degradation of the cortical cholinergic projections which project from the nucleus basalis of Meynert to the cerebral cortex. An atlas of the pathway from the nucleus basalis to the cortex (NbM cortical pathway) was constructed using diffusion tensor imaging and tractography in 87 memory clinic patients. Structural degradation was considered to be represented by lower fractional anisotropy (FA) and higher mean diffusivity (MD). Neuropsychiatric symptoms were assessed using the Neuropsychiatric Inventory. A predefined cluster including agitation, anxiety, apathy, delusions, hallucinations, and irritability was labeled as the cholinergic deficiency syndrome (CDS). In regression analyses, lower FA and higher MD in the NbM cortical pathway were associated with CDS symptoms but not with other neuropsychiatric symptoms. These associations were independent of cerebral atrophy and overall FA or MD. There was no association between interruption of the NbM cortical pathway by white matter hyperintensities and CDS symptoms. Cox regression suggested a trend for higher mortality with lower FA in the NbM cortical pathway may exist. These findings provide anatomical support for the hypothesis that degradation of the cholinergic projections from the nucleus basalis of Meynert may lead to a distinct clinical syndrome. Future studies could use our results to test the utility of assessing NbM projection integrity to identify patients who may benefit from cholinergic treatment or with a worse prognosis. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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