Associations between genetic risk, functional brain network organization and neuroticism.
Neuroticism and genetic variation in the serotonin-transporter (SLC6A4) and catechol-O-methyltransferase (COMT) gene are risk factors for psychopathology. Alterations in the functional integration and segregation of neural circuits have recently been found in individuals scoring higher on neuroticis...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 6; pp. 1581 - 1592 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126486100&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126486100 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2017 vid: 11 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126486100 126486100 143911927 NLM27743374 10.1007/s11682-016-9626-2 NLM27743374 126486100 ppf: 1581 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Associations between genetic risk, functional brain network organization and neuroticism. aug: au: Servaas, Michelle Geerligs, Linda Bastiaansen, Jojanneke Renken, Remco Marsman, Jan-Bernard Nolte, Ilja Ormel, Johan Aleman, André Riese, Harriëtte Servaas, Michelle N Bastiaansen, Jojanneke A Renken, Remco J Marsman, Jan-Bernard C Nolte, Ilja M Aleman, André Riese, Harriëtte affil: Neuroimaging Center, Department of Neuroscience , University of Groningen, University Medical Center Groningen , PO Box 196 9700 Groningen the Netherlands sug: ab: Neuroticism and genetic variation in the serotonin-transporter (SLC6A4) and catechol-O-methyltransferase (COMT) gene are risk factors for psychopathology. Alterations in the functional integration and segregation of neural circuits have recently been found in individuals scoring higher on neuroticism. The aim of the current study was to investigate how genetic risk factors impact functional network organization and whether genetic risk factors moderate the association between neuroticism and functional network organization. We applied graph theory analysis on resting-state fMRI data in a sample of 120 women selected based on their neuroticism score, and genotyped two polymorphisms: 5-HTTLPR (S-carriers and L-homozygotes) and COMT (rs4680-rs165599; COMT risk group and COMT non-risk group). For the 5-HTTLPR polymorphism, we found that subnetworks related to cognitive control show less connections with other subnetworks in S-carriers compared to L-homozygotes. The COMT polymorphism moderated the association between neuroticism and functional network organization. We found that neuroticism was associated with lower efficiency coefficients in visual and somatosensory-motor subnetworks in the COMT risk group compared to the COMT non-risk group. The findings of altered topology of specific subnetworks point to different cognitive-emotional processes that may be affected in relation to the genetic risk factors, concerning emotion regulation in S-carriers (5-HTTLPR) and emotional salience processing in COMT risk carriers. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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