Brain structure and function in patients with ovarian cancer treated with first-line chemotherapy: a pilot study.
Women with ovarian cancer often undergo chemotherapy involving multiple agents. However, little is known about treatment-related central neurotoxicity in this population. The goal of this cross-sectional study was to assess brain structure and function and neurocognitive abilities in patients with o...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 6; pp. 1652 - 1664 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126486104&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126486104 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2017 vid: 11 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126486104 126486104 144069169 NLM27766586 10.1007/s11682-016-9608-4 NLM27766586 126486104 ppf: 1652 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Brain structure and function in patients with ovarian cancer treated with first-line chemotherapy: a pilot study. aug: au: Correa, D. Root, J. Kryza-Lacombe, M. Mehta, M. Karimi, S. Hensley, M. Relkin, N. Correa, D D Root, J C Hensley, M L affil: Departments of Neurology , Memorial Sloan Kettering Cancer Center , 1275 York Avenue New York 10021 USA sug: subj: Brain Ovarian Neoplasms Drug Therapy Antineoplastic Agents Brain Physiopathology Ovarian Neoplasms Middle Age Pilot Studies Gray Matter Pathology Magnetic Resonance Imaging Gray Matter Drug Effects Brain Mapping Brain Pathology Hydrocarbons Therapeutic Use Gray Matter Memory, Short Term Neuropsychological Tests Body Weights and Measures Gray Matter Physiopathology Ovarian Neoplasms Psychosocial Factors Prospective Studies Cross Sectional Studies Platinum Compounds Ovarian Neoplasms Physiopathology Platinum Compounds Therapeutic Use Brain Drug Effects Hydrocarbons Image Processing, Computer Assisted Adult Aged Female Antineoplastic Agents Therapeutic Use Clinical Assessment Tools Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Female ab: Women with ovarian cancer often undergo chemotherapy involving multiple agents. However, little is known about treatment-related central neurotoxicity in this population. The goal of this cross-sectional study was to assess brain structure and function and neurocognitive abilities in patients with ovarian cancer following first-line chemotherapy. Eighteen patients with ovarian, peritoneal and fallopian tube cancer and eighteen healthy controls matched for gender, age and education participated in the study. The patients were evaluated 1-4 months following completion of first-line taxane/platinum chemotherapy. All participants underwent structural and functional magnetic resonance imaging (MRI), and completed neuropsychological tests of attention, memory and executive functions. Neuroimaging assessments included voxel-based morphometry (VBM) for measuring gray matter (GM) volume, and functional MRI (fMRI) during the N-back working memory task. The results of VBM showed that patients had significantly reduced GM volume compared to healthy controls in the right middle/superior frontal gyrus, and in the left supramarginal gyrus and left inferior parietal lobule. fMRI results indicated significantly decreased activation in patients relative to healthy controls in the left middle frontal gyrus and left inferior parietal lobule during the N-back task (1/2/3-back >0-back). There were no statistically significant differences between the two groups on the neuropsychological tests. This is the first study showing structural and functional alterations involving frontal and parietal regions in patients with ovarian cancer treated with first-line chemotherapy. These findings are congruent with studies involving women with breast cancer, and provide additional supporting evidence for central neurotoxicity associated with taxane/platinum chemotherapy. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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