Apoptotic and Immunosuppressive Effects of Turmeric Paste on 7, 12 Di Methyl Benz (a) Anthracene Induced Skin Tumor Model of Wistar Rat.
Dietary components with potent anticancerous property are gaining attention as therapeutic agents due to low cost of therapy and minimal toxic effects. Turmeric is one such miracle spices of Indian and South Asian recipes with multiple medicinal properties. The anticarcinogenic properties of its act...
| Publicado en: | Nutrition & Cancer Vol. 69; no. 8; pp. 1245 - 1256 |
|---|---|
| Autores principales: | , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Nov/Dec2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126497043&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126497043 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: Nov/Dec2017 vid: 69 iid: 8 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 126497043 126497043 126497043 10.1080/01635581.2017.1367933 126497043 ppf: 1245 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Apoptotic and Immunosuppressive Effects of Turmeric Paste on 7, 12 Di Methyl Benz (a) Anthracene Induced Skin Tumor Model of Wistar Rat. aug: au: Rajmani, R. S. Singh, Prafull Singh, Lakshya Veer affil: Centre for Infectious Disease Research (CIDR), Indian Institute of Science, Bengaluru, India sug: subj: Skin Neoplasms Prevention and Control Turmeric Pharmacodynamics Antineoplastic Agents Pharmacodynamics Turmeric Administration and Dosage Administration, Topical In Vivo Studies Animal Studies Rats Skin Neoplasms Chemically Induced Apoptosis Drug Effects T Lymphocytes Metabolism Statistical Significance Gene Expression Evaluation Enzymes Metabolism NF-kappa B Metabolism Vascular Endothelial Growth Factors Metabolism Killer Cells, Natural Metabolism ab: Dietary components with potent anticancerous property are gaining attention as therapeutic agents due to low cost of therapy and minimal toxic effects. Turmeric is one such miracle spices of Indian and South Asian recipes with multiple medicinal properties. The anticarcinogenic properties of its active compound curcumin have been studied in detail. However, studies on the medicinal properties of crude turmeric used as dietary agents are lacking. Therefore, in this study we investigated the effects of dietary and topical crude turmeric paste on DMBA induced skin tumor of male Wistar rats. We observed the apoptotic effect of crude turmeric paste on DMBA induced tumor with depletion of T cells response. Our results demonstrated the significant expression of major pro-apoptotic genes like caspase-2, 3, 8, 9, PARP, and p53 and down regulation of major pro-inflammatory (NF-κB) and pro-angiogenic factors and (VEGF) in turmeric treated tumor tissues. We also observed significant decrease in CD4+, CD8+, and Natural Killer cell population as compared to the untreated group. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|