Reaction Coordinate Leading to H Production in [FeFe]-Hydrogenase Identified by Nuclear Resonance Vibrational Spectroscopy and Density Functional Theory.

[FeFe]-hydrogenases are metalloenzymes that reversibly reduce protons to molecular hydrogen at exceptionally high rates. We have characterized the catalytically competent hydride state (H) in the [FeFe]-hydrogenases from both Chlamydomonas reinhardtii and Desulfovibrio desulfuricans using Fe nuclear...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 139; no. 46; pp. 16894 - 16903
Main Authors:	Pelmenschikov, Vladimir, Birrell, James A., Pham, Cindy C., Mishra, Nakul, Hongxin Wang, Sommer, Constanze, Reijerse, Edward, Richers, Casseday P., Tamasaku, Kenji, Yoda, Yoshitaka, Rauchfuss, Thomas B., Lubitz, Wolfgang, Cramer, Stephen P.
Format:	Article
Published:	American Chemical Society 11/22/2017
Subjects:	Hydrogen bonding Density functional theory Hydrogenase Chlamydomonas reinhardtii Desulfovibrio desulfuricans Chemical reactions Catalysis
Online Access:	View this record in EBSCOhost