A novel healthy blood pressure phenotype in the Long Life Family Study.
Background: Hypertension tends to run in families and has both genetic and environmental determinants. We assessed the hypothesis that a novel healthy blood pressure (BP) phenotype is also familial and sought to identify its associated factors.Methods: We developed a healthy BP phenotype in the Long...
| Publicado en: | Journal of Hypertension Vol. 36; no. 1; pp. 43 - 54 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Jan2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126553392&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126553392 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02636352 IQF jtl: Journal of Hypertension issn: 02636352 maglogo: N pubinfo: dt: Jan2018 vid: 36 iid: 1 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 126553392 126553392 NLM28837423 126553392 10.1097/HJH.0000000000001514 NLM28837423 126553392 ppf: 43 ppct: 11 formats: tig: atl: A novel healthy blood pressure phenotype in the Long Life Family Study. aug: au: Marron, Megan M. Singh, Jatinder Boudreau, Robert M. Christensen, Kaare Cosentino, Stephanie Feitosa, Mary F. Minster, Ryan L. Perls, Thomas Schupf, Nicole Sebastiani, Paola Ukraintseva, Svetlana Wojczynski, Mary K. Newman, Anne B. affil: Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. sug: subj: Phenotype Blood Pressure Blood Pressure Determination Aged, 80 and Over Male Middle Age Longevity Female Prospective Studies Adult Aged Funding Source Human Aged, 80 & over Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Male Female ab: Background: Hypertension tends to run in families and has both genetic and environmental determinants. We assessed the hypothesis that a novel healthy blood pressure (BP) phenotype is also familial and sought to identify its associated factors.Methods: We developed a healthy BP phenotype in the Long Life Family Study, a cohort of two-generation families selected for longevity. Participants from the offspring generation (n = 2211, ages 32-88) were classified as having healthy BP if their age-adjusted and sex-adjusted SBP z-score was between -1.5 and -0.5. Offspring on antihypertensive medications were classified as not having healthy BP. Families with at least two offspring (n = 419 families) were defined as meeting the healthy BP phenotype if at least two and at least 50% of their offspring had healthy BP.Results: Among 2211 offspring, 476 (21.5%) met the healthy BP phenotype. When examining the 419 families, only 44 (10.5%) families met the criteria for the healthy BP phenotype. Both offspring and probands from families with healthy BP performed better on neuropsychological tests that place demands on complex attention and executive function when compared with offspring and probands from remaining families. Among families with the healthy BP phenotype compared with families without, a higher proportion of offspring met the American Heart Association definition of ideal cardiovascular health (10.8 versus 3.8%, respectively; driven by BP, smoking status, and BMI components).Conclusion: In this cohort of familial longevity, few families had a novel healthy BP phenotype in multiple members. Families with this healthy BP phenotype may represent a specific pathway to familial longevity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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