Chemotherapy and Cognitive Impairment: An Animal Model Approach.
A substantial number of cancer survivors who undergo chemotherapy report cognitive disturbances that severely limit daily function (chemobrain). Despite supportive neuropsychological evidence, there is controversy over whether cognitive impairment is caused by the chemotherapy or is the result of po...
| Publicado en: | Canadian Journal of Experimental Psychology / Revue Canadienne de Psychologie Expérimentale Vol. 71; no. 4; pp. 265 - 274 |
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| Formato: | Artículo |
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Canadian Psychological Association
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=126560563&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 126560563 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 11961961 CJX jtl: Canadian Journal of Experimental Psychology / Revue Canadienne de Psychologie Expérimentale issn: 11961961 maglogo: N pubinfo: dt: Dec2017 vid: 71 iid: 4 pid: 98 pub: Canadian Psychological Association artinfo: ui: 126560563 10.1037/cep0000144 ppf: 265 ppct: 9 formats: fmt: @attributes: type: P size: 1008KB tig: atl: Chemotherapy and Cognitive Impairment: An Animal Model Approach. aug: au: Winocur, Gordon affil: Baycrest Health Sciences; University of Toronto Trent University su: Drug side effects Antineoplastic agents Biological models Cancer chemotherapy Cognition disorders Hippocampus (Brain) Rodents Mathematical variables Donepezil sug: subj: Drug side effects All other miscellaneous animal production Antineoplastic agents Biological models Cancer chemotherapy Cognition disorders Hippocampus (Brain) Rodents Mathematical variables Donepezil keyword: chemotherapy cognitive impairment preclinical research chimiothérapie déficience cognitive recherche préclinique chemotherapy cognitive impairment preclinical research chimiothérapie déficience cognitive recherche préclinique ab: A substantial number of cancer survivors who undergo chemotherapy report cognitive disturbances that severely limit daily function (chemobrain). Despite supportive neuropsychological evidence, there is controversy over whether cognitive impairment is caused by the chemotherapy or is the result of potentially confounding factors that include the disease itself, age, and psychological stress. Our research program, conducted on rodents, has confirmed that a range of cognitive processes, mediated in particular by hippocampal and prefrontal brain regions, are affected by anticancer drugs in combination with tumor development and that many of the effects are long lasting. This work has also provided evidence of protective factors (cognitive reserve, physical exercise, environmental enrichment) and the potential of pharmacological treatment (donepezil) interventions in reducing these effects. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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