Non-invasive monitoring of the therapeutic response in sorafenib-treated hepatocellular carcinoma based on photoacoustic imaging.
Purpose: We investigated the changes of tissue oxygen saturation (sO2) in sorafenib-treated HCC (hepatocelluar carcinoma) mouse models using photoacoustic imaging (PI).Materials and Methods: Nude mice, implanted with human HCC (HepG2-RFP) cells in the liver, were randomised to the sorafenib-treated...
| Publicado en: | European Radiology Vol. 28; no. 1; pp. 372 - 382 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jan2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126562786&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126562786 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jan2018 vid: 28 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126562786 126562786 144042482 NLM28752217 10.1007/s00330-017-4960-3 NLM28752217 126562786 ppf: 372 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Non-invasive monitoring of the therapeutic response in sorafenib-treated hepatocellular carcinoma based on photoacoustic imaging. aug: au: Lee, Seunghyun Kim, Jung Hoon Lee, Jae Hwan Lee, Jeong Hwa Han, Joon Koo affil: Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea sug: subj: Urea Therapeutic Use Liver Neoplasms Acoustics Methods Vitamin B Complex Carcinoma, Hepatocellular Cell Line, Tumor Animals Liver Neoplasms Drug Therapy Vitamin B Complex Therapeutic Use Carcinoma, Hepatocellular Drug Therapy Mice Antineoplastic Agents Therapeutic Use ab: Purpose: We investigated the changes of tissue oxygen saturation (sO2) in sorafenib-treated HCC (hepatocelluar carcinoma) mouse models using photoacoustic imaging (PI).Materials and Methods: Nude mice, implanted with human HCC (HepG2-RFP) cells in the liver, were randomised to the sorafenib-treated group (n = 21) or the control group (n = 20). Tumour volume and sO2 were measured by PI at baseline and then one week later, and radiant efficiency (RE) and therapeutic response were analysed by fluorescence imaging and histologic analysis.Results: Sorafenib was effective in treating HCC by evaluating necrotic fraction, apoptosis index, and microvessel density (MVD). One week after treatment, the sO2 of HCC and residual healthy liver tissue decreased, and the hypoxia inducible factor-1α (HIF-1α) protein expression of HCC increased, correlating with the apoptosis index. The ΔsO2 in HCC showed a significantly positive correlation with the necrotic fraction and the apoptosis index of tumour and a negative correlation with the MVD of tumour.Conclusion: Sorafenib treatment results in changes of sO2 in HCC and liver parenchyma and induces the accumulation of HIF-1α by hypoxic environment. sO2 as measured by PI, can be a useful marker for non-invasive monitoring of the therapeutic response in orthotopic HCC mouse models.Key Points: • Hypoxia is a characteristic feature of the tumour microenvironment • It is important to monitor sO 2 in HCC during sorafenib treatment • PI is useful for non-invasive monitoring of sO 2 in HCC. • ΔsO 2 in HCC showed a significantly correlation with tumour response. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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