Retained executive abilities in mild cognitive impairment are associated with increased white matter network connectivity.
Purpose: To describe structural network differences in individuals with mild cognitive impairment (MCI) with high versus low executive abilities, as reflected by measures of white matter connectivity using diffusion tensor imaging (DTI).Materials and Methods: This was a retrospective, cross-sectiona...
| Publicado en: | European Radiology Vol. 28; no. 1; pp. 340 - 348 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jan2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126562793&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126562793 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jan2018 vid: 28 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126562793 126562793 144094511 NLM28695358 10.1007/s00330-017-4951-4 NLM28695358 126562793 ppf: 340 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Retained executive abilities in mild cognitive impairment are associated with increased white matter network connectivity. aug: au: Farrar, Danielle C. Mian, Asim Z. Budson, Andrew E. Moss, Mark B. Koo, Bang Bon Killiany, Ronald J. for the Alzheimer’s Disease Neuroimaging Initiative affil: Department of Anatomy and Neurobiology, Boston University School of Medicine, 650 Albany St, Basement, 02118, Boston, MA, USA sug: subj: Brain Physiopathology Magnetic Resonance Imaging Methods Executive Function Brain Resource Databases Retrospective Design Male Female Aged Cross Sectional Studies Aged: 65+ years Male Female ab: Purpose: To describe structural network differences in individuals with mild cognitive impairment (MCI) with high versus low executive abilities, as reflected by measures of white matter connectivity using diffusion tensor imaging (DTI).Materials and Methods: This was a retrospective, cross-sectional study. Of the 128 participants from the Alzheimer's Disease Neuroimaging Initiative database who had both a DTI scan as well as a diagnosis of MCI, we used an executive function score to classify the top 15 scoring patients as high executive ability, and the bottom-scoring 16 patients as low executive ability. Using a regions-of-interest-based analysis, we constructed networks and calculated graph theory measures on the constructed networks. We used automated tractography in order to compare differences in major white matter tracts.Results: The high executive ability group yielded greater network size, density and clustering coefficient. The high executive ability group reflected greater fractional anisotropy bilaterally in the inferior and superior longitudinal fasciculi.Conclusions: The network measures of the high executive ability group demonstrated greater white matter integrity. This suggests that white matter reserve may confer greater protection of executive abilities. Loss of this reserve may lead to greater impairment in the progression to Alzheimer's disease dementia.Key Points: • The MCI high executive ability group yielded a larger network. • The MCI high executive ability group had greater FA in numerous tracts. • White matter reserve may confer greater protection of executive abilities. • Loss of executive reserve may lead to greater impairment in AD dementia. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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