Diagnostic accuracy of serum antibodies to human papillomavirus type 16 early antigens in the detection of human papillomavirus-related oropharyngeal cancer.
Background: Because of the current epidemic of human papillomavirus (HPV)-related oropharyngeal cancer (OPC), a screening strategy is urgently needed. The presence of serum antibodies to HPV-16 early (E) antigens is associated with an increased risk for OPC. The purpose of this study was to evaluate...
| Publicado en: | Cancer (0008543X) Vol. 123; no. 24; pp. 4886 - 4895 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126563722&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126563722 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0008543X 23I jtl: Cancer (0008543X) issn: 0008543X maglogo: Y pubinfo: dt: Dec2017 vid: 123 iid: 24 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 126563722 126563722 NLM28898394 126563722 10.1002/cncr.30955 NLM28898394 126563722 ppf: 4886 ppct: 9 formats: tig: atl: Diagnostic accuracy of serum antibodies to human papillomavirus type 16 early antigens in the detection of human papillomavirus-related oropharyngeal cancer. aug: au: Dahlstrom, Kristina R. Anderson, Karen S. Field, Matthew S. Chowell, Diego Ning, Jing Li, Nan Wei, Qingyi Li, Guojun Sturgis, Erich M. affil: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston Texas sug: subj: Antibodies, Viral Blood Papillomavirus Infections Diagnosis Oropharyngeal Neoplasms Diagnosis Papillomaviruses Oropharyngeal Neoplasms Sensitivity and Specificity Female In Situ Hybridization Oropharyngeal Neoplasms Epidemiology Demography Papillomavirus Infections Complications Adult Middle Age Academic Medical Centers Male Prognosis Logistic Regression Immunohistochemistry Risk Assessment Texas Incidence Aged Enzyme-Linked Immunosorbent Assay Reference Values Case Control Studies Biopsy, Needle Funding Source Human Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Background: Because of the current epidemic of human papillomavirus (HPV)-related oropharyngeal cancer (OPC), a screening strategy is urgently needed. The presence of serum antibodies to HPV-16 early (E) antigens is associated with an increased risk for OPC. The purpose of this study was to evaluate the diagnostic accuracy of antibodies to a panel of HPV-16 E antigens in screening for OPC.Methods: This case-control study included 378 patients with OPC, 153 patients with nonoropharyngeal head and neck cancer (non-OPC), and 782 healthy control subjects. The tumor HPV status was determined with p16 immunohistochemistry and HPV in situ hybridization. HPV-16 E antibody levels in serum were identified with an enzyme-linked immunosorbent assay. A trained binary logistic regression model based on the combination of all E antigens was predefined and applied to the data set. The sensitivity and specificity of the assay for distinguishing HPV-related OPC from controls were calculated. Logistic regression analysis was used to calculate odds ratios with 95% confidence intervals for the association of head and neck cancer with the antibody status.Results: Of the 378 patients with OPC, 348 had p16-positive OPC. HPV-16 E antibody levels were significantly higher among patients with p16-positive OPC but not among patients with non-OPC or among controls. Serology showed high sensitivity and specificity for HPV-related OPC (binary classifier: 83% sensitivity and 99% specificity for p16-positive OPC).Conclusions: A trained binary classification algorithm that incorporates information about multiple E antibodies has high sensitivity and specificity and may be advantageous for risk stratification in future screening trials. Cancer 2017;123:4886-94. © 2017 American Cancer Society. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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