Association between Fluorescent Advanced Glycation End-Products and Vascular Complications in Type 2 Diabetic Patients.
Objectives. Diabetes is a major health problem associated with hyperglycemia and chronically increased oxidative stress and enhanced formation of advanced glycation end-products (AGEs). The aim of this study was to determine whether oxidative plasma biomarkers in diabetic patients could be evidenced...
| Publicado en: | BioMed Research International Vol. 2017; pp. 1 - 11 |
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| Autores principales: | , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
12/6/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126596547&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126596547 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 12/6/2017 vid: 2017 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 126596547 126596547 126596547 10.1155/2017/7989180 126596547 ppf: 1 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Association between Fluorescent Advanced Glycation End-Products and Vascular Complications in Type 2 Diabetic Patients. aug: au: Guerin-Dubourg, Alexis Cournot, Maxime Planesse, Cynthia Debussche, Xavier Meilhac, Olivier Rondeau, Philippe Bourdon, Emmanuel affil: Université de La Réunion, INSERM, UMR 1188 Diabète Athérothrombose Thérapies Réunion Océan Indien (DéTROI), Saint-Denis de La Réunion, France sug: subj: Glycation End Products, Advanced Fluorescence Polarization Diabetic Patients Evaluation Diabetes Mellitus, Type 2 Complications Human Vascular Diseases Complications Hyperglycemia Complications Chronic Disease Oxidative Stress Plasma Biological Markers Ischemia Physiopathology Albumins Glycemic Control Evaluation Control Group Middle Age Middle Aged: 45-64 years ab: Objectives. Diabetes is a major health problem associated with hyperglycemia and chronically increased oxidative stress and enhanced formation of advanced glycation end-products (AGEs). The aim of this study was to determine whether oxidative plasma biomarkers in diabetic patients could be evidenced and associated with vascular complications. Methods. Oxidative stress biomarkers such as thiols, ischemia-modified albumin (IMA), glycated albumin (GA), fructosamine, and AGEs were measured in 75 patients with poorly controlled type 2 diabetes (HbA1c > 7.5%) with (44) or without (31) vascular disease and in 31 nondiabetic controls. Results. Most biomarkers of oxidation and glycation were significantly increased in diabetic patients in comparison with nondiabetics. Fructosamines, GA, IMA, and AGEs were positively correlated and levels of fluorescent AGEs were significantly increased in the plasma from patients presenting vascular complication. Conclusions. These results bring new evidence for the potential interest of glycated albumin, oxidative stress, and glycoxidation parameters in the monitoring of type 2 diabetic patients. Furthermore, it emphasizes fluorescent AGEs as a putative indicator for vascular event prediction in diabetic patients. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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