Ionic Liquid Droplet Microreactor for Catalysis Reactions Not at Equilibrium.
We develop a novel strategy to more effectively and controllably process continuous enzymatic or homogeneous catalysis reactions based on nonaqueous Pickering emulsions. A key element of this strategy is "bottom-up" construction of a macroscale continuous flow reaction system through packing catalys...
| Published in: | Journal of the American Chemical Society Vol. 139; no. 48; pp. 17387 - 17397 |
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| Main Authors: | , , , , , , |
| Format: | Article |
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American Chemical Society
12/6/2017
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=126761790&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 126761790 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 12/6/2017 vid: 139 iid: 48 pid: 997 pub: American Chemical Society artinfo: ui: 126761790 10.1021/jacs.7b07731 ppf: 17387 ppct: 10 formats: tig: atl: Ionic Liquid Droplet Microreactor for Catalysis Reactions Not at Equilibrium. aug: au: Ming Zhang Ettelaie, Rammile Tao Yan Suojiang Zhang Fangqin Cheng Binks, Bernard P. Hengquan Yang affil: School of Chemistry and Chemical Engineering, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China Food Colloids Group, School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, United Kingdom Beijing Key Laboratory of Ionic Liquids Clean Process, Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China Institute of Resources and Environment Engineering, Shanxi University, Taiyuan 030006, China School of Mathematics and Physical Sciences, University of Hull, Hull HU6 7RX, United Kingdom su: Microreactors Ionic liquids Emulsions Continuous flow reactors Ring formation (Chemistry) sug: subj: Microreactors Ionic liquids Emulsions Continuous flow reactors Ring formation (Chemistry) ab: We develop a novel strategy to more effectively and controllably process continuous enzymatic or homogeneous catalysis reactions based on nonaqueous Pickering emulsions. A key element of this strategy is "bottom-up" construction of a macroscale continuous flow reaction system through packing catalyst-containing micron-sized ionic liquid (IL) droplet in oil in a column reactor. Due to the continuous influx of reactants into the droplet microreactors and the continuous release of products from the droplet microreactors, catalysis reactions in such a system can take place without limitations arising from establishment of the reaction equilibrium and catalyst separation, inherent in conventional batch reactions. As proof of the concept, enzymatic enantioselective transesterification and CuI-catalyzed cycloaddition reactions using this IL droplet-based flow system both exhibit 8 to 25-fold enhancement in catalysis efficiency compared to their batch counterparts, and a durability of at least 4000 h for the enantioselective trans-esterification of 1-phenylethyl alcohol, otherwise unattainable in their batch counterparts. We further establish a theoretical model for such a catalysis system working under nonequilibrium conditions, which not only supports the experimental results but also helps to predict reaction progress at a microscale level. Being operationally simple, efficient, and adaptive, this strategy provides an unprecedented platform for practical applications of enzymes and homogeneous catalysts even at a controllable level. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2017 holdings: @attributes: islocal: N |
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