Antibiotic Resistance Trends in Methicillin-Resistant Staphylococcus aureus Isolated in Kuwait Hospitals: 2011-2015.
Objective: The aim of this study was to determine antibiotic resistance trends and carriage of staphylococcal cassette chromosome mec (SCCmec) genetic elements in methicillin-resistant Staphylococcus aureus (MRSA) isolated in Kuwait hospitals to ascertain whether they were healthcare associated (HA-...
| Publicado en: | Medical Principles & Practice Vol. 26; no. 5; pp. 485 - 491 |
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| Autores principales: | , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Karger AG
Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126786008&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126786008 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10117571 NJW jtl: Medical Principles & Practice issn: 10117571 maglogo: N pubinfo: dt: Dec2017 vid: 26 iid: 5 pid: 2485 pub: Karger AG artinfo: ui: 126786008 126786008 NLM28977793 126786008 10.1159/000481944 NLM28977793 126786008 ppf: 485 ppct: 6 formats: tig: atl: Antibiotic Resistance Trends in Methicillin-Resistant Staphylococcus aureus Isolated in Kuwait Hospitals: 2011-2015. aug: au: Udo, Edet E. Boswihi, Samar S. affil: Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait sug: subj: Bacterial Proteins Antibiotics Pharmacodynamics Hospitals Drug Resistance, Microbial Drug Effects Methicillin-Resistant Staphylococcus Aureus Drug Effects Methicillin-Resistant Staphylococcus Aureus Drug Resistance, Microbial Genotype Cross Infection Microbiology Kuwait Microbial Culture and Sensitivity Tests Human ab: Objective: The aim of this study was to determine antibiotic resistance trends and carriage of staphylococcal cassette chromosome mec (SCCmec) genetic elements in methicillin-resistant Staphylococcus aureus (MRSA) isolated in Kuwait hospitals to ascertain whether they were healthcare associated (HA-MRSA) or community associated (CA-MRSA).Materials and Methods: In total, 6,922 MRSA isolates obtained from different clinical samples were tested for resistance to antibiotics, urease production, and carriage of SCCmec elements.Results: All MRSA isolates were susceptible to linezolid, vancomycin, and teicoplanin. However, some isolates were resistant to kanamycin (2,979; 43%), ciprofloxacin (2,955; 42.7%), erythromycin and clindamycin (2,935; 42.4%), fusidic acid (2,858; 41.2%), gentamicin (2,665; 38.5%), tetracycline (2,652; 38.3%), and trimethoprim (2,324; 33.5%). Whereas the prevalence of resistance to most antibiotics showed annual variations, those resistant to chloramphenicol and rifampicin increased from 2.6 and 0.1% to 9.6 and 1.6%, respectively, and high-level mupirocin resistance declined from 9.3% in 2011 to 3.6% in 2015. In total, 3,244 (53.9%) of the isolates carried SCCmec IV followed by SCCmec III (1,737; 28.8%) and SCCmec V (890; 14.8%). SCCmec I (21; 0.3%) and II (79; 0.8%) occurred sporadically. A total of 3,651 (60.7%) of the isolates belonged to the CA-MRSA genotype and 2,290 isolates (38.1%) were identified as HA-MRSA.Conclusion: This study demonstrates changes in antibiotic resistance patterns of MRSA over time and reinforces the value of surveillance in detecting such changes for the benefit of infection control and patient management. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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