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Taking Multiple Exposure Into Account Can Improve Assessment of Chemical Risks.

During work, operators may be exposed to several chemicals simultaneously. Most exposure assessment approaches only determine exposure levels for each substance individually. However, such individual-substance approaches may not correctly estimate the toxicity of 'cocktails' of chemicals, as the tox...

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Published in:Annals of Work Exposures & Health Vol. 62; no. 1; pp. 53 - 62
Main Authors: Clerc, Frédéric, Hyacinthe Bertrand, Nicolas Jean, Rocca, Bénédicte La
Format: research tables/charts Journal Article
Published: Oxford University Press / USA Jan2018
Online Access:View this record in EBSCOhost
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      dt: Jan2018
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      pub: Oxford University Press / USA
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        atl: Taking Multiple Exposure Into Account Can Improve Assessment of Chemical Risks.
      aug:
        au:
          Clerc, Frédéric
          Hyacinthe Bertrand, Nicolas Jean
          Rocca, Bénédicte La
        affil: INRS--rue du Morvan, 54500 Vandoeuvre-lès-Nancy, France
      sug:
        subj:
          Occupational Exposure
          Risk Assessment Methods
          Hazardous Materials Analysis
          Toxicity Tests
          Sample Size
          Databases Utilization
          Data Analysis Software
          Retrospective Design
          Descriptive Statistics
          France
          Work Environment
      ab: During work, operators may be exposed to several chemicals simultaneously. Most exposure assessment approaches only determine exposure levels for each substance individually. However, such individual-substance approaches may not correctly estimate the toxicity of 'cocktails' of chemicals, as the toxicity of a cocktail may differ from the toxicity of substances on their own. This study presents an approach that can better take into account multiple exposure when assessing chemical risks. Almost 30 000 work situations, monitored between 2005 and 2014 and recorded in two French databases, were analysed using MiXie software. The algorithms employed in MiXie can identify toxicological classes associated with several substances, based on the additivity of the selected effects of each substance. The results of our retrospective analysis show that MiXie was able to identify almost 20% more potentially hazardous situations than identified using a single-substance approach. It therefore appears essential to review the ways in which multiple exposure is taken into account during risk assessment.
      pubtype: Academic Journal
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        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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