A Postmortem Study of Frontal and Temporal Gyri Thickness and Cell Number in Human Obesity.
Objective: This study aimed to compare cortex thickness and neuronal cell density in postmortem brain tissue from people with overweight or obesity and normal weight.Methods: The cortex thickness and neuron density of eight donors with overweight or obesity (mean = 31.6 kg/m2 ; SD = 4.35; n = 8; 6 m...
| Publicado en: | Obesity (19307381) Vol. 26; no. 1; pp. 94 - 103 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jan2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126886746&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126886746 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19307381 GSO jtl: Obesity (19307381) issn: 19307381 maglogo: Y pubinfo: dt: Jan2018 vid: 26 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 126886746 126886746 NLM29131517 126886746 10.1002/oby.22036 NLM29131517 126886746 ppf: 94 ppct: 9 formats: tig: atl: A Postmortem Study of Frontal and Temporal Gyri Thickness and Cell Number in Human Obesity. aug: au: Gómez‐Apo, Erick García‐Sierra, Adrián Silva‐Pereyra, Juan Soto‐Abraham, Virgilia Mondragón‐Maya, Alejandra Velasco‐Vales, Verónica Pescatello, Linda S. affil: Neuroscience Project, Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, Mexico City, Mexico sug: subj: Brain Pathology Temporal Lobe Abnormalities Obesity Diagnosis Cell Count Equipment and Supplies Frontal Lobe Abnormalities Male Female Cell Count Methods Middle Age Temporal Lobe Pathology Adult Autopsy Obesity Pathology Adolescence Human Middle Aged: 45-64 years Adult: 19-44 years Adolescent: 13-18 years Male Female ab: Objective: This study aimed to compare cortex thickness and neuronal cell density in postmortem brain tissue from people with overweight or obesity and normal weight.Methods: The cortex thickness and neuron density of eight donors with overweight or obesity (mean = 31.6 kg/m2 ; SD = 4.35; n = 8; 6 male) and eight donors with normal weight (mean = 21.8 kg/m2 ; SD = 1.5; n = 8; 5 male) were compared. All participants were Mexican and lived in Mexico City. Randomly selected thickness measures of different cortex areas from the frontal and temporal lobes were analyzed based on high-resolution real-size photographs. A histological analysis of systematic-random fields was used to quantify the number of neurons in postmortem left and right of the first, second, and third gyri of frontal and temporal lobe brain samples.Results: No statistical difference was found in cortical thickness between donors with overweight or obesity and individuals with normal weight. A smaller number of neurons was found among the donors with overweight or obesity than the donors with normal weight at different frontal and temporal areas.Conclusions: A lower density of neurons is associated with overweight or obesity. The morphological basis for structural brain changes in obesity requires further investigation. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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