Myocardial iodine concentration measurement using dual-energy computed tomography for the diagnosis of cardiac amyloidosis: a pilot study.
Objective: To measure myocardium iodine concentration (MIC) in patients with cardiac amyloidosis (CA) using dual-energy computed tomography (DECT).Methods: Twenty-two patients with CA, 13 with non-amyloid hypertrophic cardiomyopathies (CH) and 10 control patients were explored with pre-contrast, art...
| Publicado en: | European Radiology Vol. 28; no. 2; pp. 816 - 824 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126970465&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126970465 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2018 vid: 28 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 126970465 126970465 143969040 NLM28812126 126970465 10.1007/s00330-017-4984-8 NLM28812126 126970465 ppf: 816 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Myocardial iodine concentration measurement using dual-energy computed tomography for the diagnosis of cardiac amyloidosis: a pilot study. aug: au: Chevance, Virgile Damy, Thibaud Tacher, Vania Legou, François Ridouani, Fourat Luciani, Alain Kobeiter, Hicham Rahmouni, Alain Deux, Jean-François affil: Service d’Imagerie Médicale, AP-HP (Assistance Publique-Hôpitaux de Paris, Créteil), Groupe Hospitalier Henri Mondor-Albert Chenevier, F-94000, Créteil, France sug: subj: Amyloidosis Iodine Metabolism Tomography, X-Ray Computed Methods Myocardium Metabolism Myocardial Diseases Pilot Studies Aged Radiographic Image Interpretation, Computer-Assisted Cardiomyopathy, Hypertrophic Myocardial Diseases Metabolism Male Female Amyloidosis Metabolism Human Aged: 65+ years Male Female ab: Objective: To measure myocardium iodine concentration (MIC) in patients with cardiac amyloidosis (CA) using dual-energy computed tomography (DECT).Methods: Twenty-two patients with CA, 13 with non-amyloid hypertrophic cardiomyopathies (CH) and 10 control patients were explored with pre-contrast, arterial and 5-minute DECT acquisition (Iomeprol; 1.5 mL/kg). Inter-ventricular septum (IVS) thickness, blood pool iodine concentration (BPIC), MIC (mg/mL), iodine ratio and extra-cellular volume (ECV) were calculated.Results: IVS thickness was significantly (p < 0.001) higher in CA (17 ± 4 mm) and CH (15 ± 3 mm) patients than in control patients (10 ± 1 mm). CA patients exhibited significantly (p < 0.001) higher 5-minute MIC [2.6 (2.3-3.1) mg/mL], 5-minute iodine ratio (0.88 ± 0.12) and ECV (0.56 ± 0.07) than CH [1.7 (1.4-2.2) mg/mL, 0.57 ± 0.07 and 0.36 ± 0.05, respectively] and control patients [1.9 (1.7-2.4) mg/mL, 0.58 ± 0.07 and 0.35 ± 0.04, respectively). CH and control patients exhibited similar values (p = 0.9). The area under the curve of 5-minute iodine ratio for the differential diagnosis of CA from CH patients was 0.99 (0.73-1.0; p = 0.001). With a threshold of 0.65, the sensitivity and specificity of 5-minute iodine ratio were 100% and 92%, respectively.Conclusion: Five-minute MIC and iodine ratio were increased in CA patients and exhibited best diagnosis performance to diagnose CA in comparison to other parameters.Key Point: • Dual-energy computed tomography can be used to detect cardiac amyloidosis • Five-minute myocardial iodine concentration and iodine ratio increase in cardiac amyloidosis • Among iodine parameters, 5-minute iodine ratio has the best diagnosis performance. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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