Evaluation of the Flagging Performance of the Hematology Analyzer Sysmex XN Series on the Basis of ''Q Values''.
Context.--In the XN series of hematology analyzers (Sysmex, Kobe, Japan), the probability of the presence of abnormal cells is indicated by flags based on Q values. Objective.--To evaluate the Q value performance of the Sysmex XN-20 modular analyzer. Design.--The interinstrumental concordance, intra...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 142; no. 1; pp. 83 - 89 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
College of American Pathologists
Jan2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=126986871&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 126986871 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Jan2018 vid: 142 iid: 1 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 126986871 126986871 126986871 10.5858/arpa.2016-0502-OA 126986871 ppf: 83 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Evaluation of the Flagging Performance of the Hematology Analyzer Sysmex XN Series on the Basis of ''Q Values''. aug: au: Oh Joo Kweon Mi-Kyung Lee Hye Ryoun Kim affil: Department of Laboratory Medicine, Aerospace Medical Center, Republic of Korea Air Force, Cheongju, Republic of Korea sug: subj: Hematology Equipment and Supplies Laboratory Equipment and Supplies Autoanalyzers Lymphocytes Precision Descriptive Statistics Sensitivity and Specificity Cell Count Human ab: Context.--In the XN series of hematology analyzers (Sysmex, Kobe, Japan), the probability of the presence of abnormal cells is indicated by flags based on Q values. Objective.--To evaluate the Q value performance of the Sysmex XN-20 modular analyzer. Design.--The interinstrumental concordance, intrainstrumental precision, and diagnostic accuracy of Q values, with tested flags of ''blasts/abnormal lymphocytes,'' ''atypical lymphocytes,'' and ''blasts,'' were investigated. Results.--Absolute concordance rates in flagging between 2 analyzers ranged from 69.8% to 80.8%, and j values ranged from 0.43 to 0.61. In samples with absolute related cell counts lower than 100/lL, the values ranged from 0.31 to 0.52. For intrainstrumental precision, standard deviations ranged from 4.8 to 23.9 for the blasts/abnormal lymphocytes, from 18.7 to 59.1 for the blasts, and from 11.0 to 23.0 for the atypical lymphocytes. Using a default Q value cutoff, diagnostic accuracy values based on the area under the curve, sensitivity, and specificity were, respectively, 0.910, 90.9%, and 72.2% for blasts/abnormal lymphocytes; 0.927, 84.9%, and 89.8% for blasts; and 0.865, 74.4%, and 84.9% for atypical lymphocytes. The diagnostic accuracy of Q values was much lower in samples with absolute related cell counts lower than 100/lL than in those 100/lL or higher. Conclusions.--Q values of the Sysmex XN-20 analyzer were found to be imprecise and irreproducible, especially with samples containing a small number of pathologic cells. Adjustments in the Q value threshold may help in the detection of these cells. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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