Association between mammographic breast density and histologic features of benign breast disease.
Background: Over 40% of women undergoing breast screening have mammographically dense breasts. Elevated mammographic breast density (MBD) is an established breast cancer risk factor and is known to mask tumors within the dense tissue. However, the association of MBD with high risk benign breast dise...
| Published in: | Breast Cancer Research Vol. 19; pp. 1 - 11 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Journal Article |
| Published: |
BioMed Central
12/19/2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127009334&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127009334 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14655411 8UYJ jtl: Breast Cancer Research issn: 14655411 maglogo: N pubinfo: dt: 12/19/2017 vid: 19 pid: 24147 pub: BioMed Central artinfo: ui: 127009334 127009334 NLM29258587 10.1186/s13058-017-0922-6 NLM29258587 127009334 ppf: 1 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Association between mammographic breast density and histologic features of benign breast disease. aug: au: Ghosh, Karthik Vierkant, Robert A. Frank, Ryan D. Winham, Stacey Visscher, Daniel W. Pankratz, Vernon S. Scott, Christopher G. Brandt, Kathleen Sherman, Mark E. Radisky, Derek C. Frost, Marlene H. Hartmann, Lynn C. Degnim, Amy C. Vachon, Celine M. affil: General Internal Medicine, Breast Diagnostic Clinic, Mayo Clinic, 200 First Street SW, Rochester, MN, USA sug: subj: Mammography Breast Diseases Breast Diseases Pathology Adult Odds Ratio Biopsy Female Prospective Studies Fibrosis Population Surveillance Aged Young Adult Middle Age Breast Diseases Epidemiology Barthel Index Checklists Psychological Tests Scales Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female ab: Background: Over 40% of women undergoing breast screening have mammographically dense breasts. Elevated mammographic breast density (MBD) is an established breast cancer risk factor and is known to mask tumors within the dense tissue. However, the association of MBD with high risk benign breast disease (BBD) is unknown.Method: We analyzed data for 3400 women diagnosed with pathologically confirmed BBD in the Mayo Clinic BBD cohort from 1985-2001, with a clinical MBD measure (either parenchymal pattern (PP) or Breast Imaging Reporting and Data Systems (BI-RADS) density) and expert pathology review. Risk factor information was collected from medical records and questionnaires. MBD was dichotomized as dense (PP classification P2 or DY, or BI-RADS classification c or d) or non-dense (PP classification N1 or P1, or BI-RADS classification a or b). Associations of clinical and histologic characteristics with MBD were examined using logistic regression analysis to estimate odds ratios (ORs) with 95% confidence intervals (CIs).Results: Of 3400 women in the study, 2163 (64%) had dense breasts. Adjusting for age and body mass index (BMI), there were positive associations of dense breasts with use of hormone therapy (HT), lack of lobular involution, presence of atypical lobular hyperplasia (ALH), histologic fibrosis, columnar cell hyperplasia/flat epithelia atypia (CCH/FEA), sclerosing adenosis (SA), cyst, usual ductal hyperplasia, and calcifications. In fully adjusted multivariate models, HT (1.3, 95% CI 1.1-1.5), ALH (1.5, 95% CI 1.0-2.2), lack of lobular involution (OR 1.6, 95% CI 1.2-2.1, compared to complete involution), fibrosis (OR 2.2, 95% CI 1.9-2.6) and CCH/FEA (OR 1.3, 95% CI 1.0-1.6) remained significantly associated with high MBD.Conclusion: Our findings support an association between high risk BBD and high MBD, suggesting that risks associated with the latter may act early in breast carcinogenesis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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