Chart validation of inpatient ICD-9-CM administrative diagnosis codes for ischemic stroke among IGIV users in the Sentinel Distributed Database.
The Sentinel Distributed Database (SDD) is a large database of patient-level medical and prescription records, primarily derived from insurance claims and electronic health records, and is sponsored by the U.S. Food and Drug Administration for drug safety assessments. In this chart validation study,...
| Published in: | Medicine Vol. 96; no. 52; pp. 1 - 7 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Lippincott Williams & Wilkins
12/29/2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127040651&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127040651 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00257974 2S6 jtl: Medicine issn: 00257974 maglogo: N pubinfo: dt: 12/29/2017 vid: 96 iid: 52 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 127040651 127040651 NLM29384925 127040651 10.1097/MD.0000000000009440 NLM29384925 127040651 ppf: 1 ppct: 6 formats: tig: atl: Chart validation of inpatient ICD-9-CM administrative diagnosis codes for ischemic stroke among IGIV users in the Sentinel Distributed Database. aug: au: Ammann, Eric M. Leira, Enrique C. Winiecki, Scott K. Nagaraja, Nandakumar Dandapat, Sudeepta Carnahan, Ryan M. Schweizer, Marin L. Torner, James C. Fuller, Candace C. Leonard, Charles E. Garcia, Crystal Pimentel, Madelyn Chrischilles, Elizabeth A. affil: College of Public Health, University of Iowa, Iowa City, IA sug: subj: Immunologic Factors Therapeutic Use Immunoglobulins, Intravenous Therapeutic Use Cerebral Ischemia Diagnosis Hospitalization International Classification of Diseases Stroke Diagnosis Predictive Value of Tests Middle Age Aged Young Adult Female Adult Child Infant, Newborn United States Male Aged, 80 and Over Resource Databases Adolescence Infant Child, Preschool Human Middle Aged: 45-64 years Aged: 65+ years Adult: 19-44 years Child: 6-12 years Infant, Newborn: birth-1 month Aged, 80 & over Adolescent: 13-18 years Infant: 1-23 months Child, Preschool: 2-5 years Female Male ab: The Sentinel Distributed Database (SDD) is a large database of patient-level medical and prescription records, primarily derived from insurance claims and electronic health records, and is sponsored by the U.S. Food and Drug Administration for drug safety assessments. In this chart validation study, we report on the positive predictive value (PPV) of inpatient ICD-9-CM acute ischemic stroke (AIS) administrative diagnosis codes (433.x1, 434.xx, and 436) in the SDD.As part of an assessment of the risk of thromboembolic adverse events following treatment with intravenous immune globulin (IGIV), charts were obtained for 131 potential post-IGIV AIS cases. Charts were abstracted by trained nurses and then adjudicated by stroke experts using pre-specified diagnostic criteria.Case status could be determined for 128 potential AIS cases, of which 34 were confirmed. The PPVs for the inpatient AIS diagnoses recorded in the SDD were 27% overall [95% confidence interval (95% CI): 19-35], 60% (95% CI: 32-84) for principal-position diagnoses, 42% (95% CI: 28-57) for secondary diagnoses, and 6% (95% CI: 2-15) for position-unspecified diagnoses (which in the SDD generally originate from separate physician claims associated with an inpatient stay).Position-unspecified diagnoses were unlikely to represent true AIS cases. PPVs for principal and secondary inpatient diagnosis codes were higher, but still meaningfully lower than estimates from prior chart validation studies. The low PPVs may be specific to the IGIV user study population. Additional research is needed to assess the validity of AIS administrative diagnosis codes in other study populations within the SDD. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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