Role of the guanine nucleotide binding protein, Gα in the development of morphine tolerance and dependence.
Rationale: The use of morphine and other opioids for chronic pain is limited by the development of analgesic tolerance and physical dependence. Morphine produces its effects by activating the μ opioid receptor, which couples to Gα-containing heterotrimeric G proteins. Evidence suggests that the anti...
| Published in: | Psychopharmacology Vol. 235; no. 1; pp. 71 - 83 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Jan2018
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| Online Access: | View this record in EBSCOhost |