Agreement between manual relaxometry and semi-automated scanner-based multi-echo Dixon technique for measuring liver T2* in a pediatric and young adult population.
Background: Commercially available 3D multi-echo Dixon (mDixon) sequences provide parametric maps of liver T2*, obviating manual curve fitting that is often required with conventional gradient recalled echo (GRE)-based multi-echo relaxometry, potentially simplifying clinical work flow.Objective: The...
| Publicado en: | Pediatric Radiology Vol. 48; no. 1; pp. 94 - 101 |
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| Autores principales: | , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127041620&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127041620 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Jan2018 vid: 48 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 127041620 127041620 144176457 NLM29058039 127041620 10.1007/s00247-017-3990-y NLM29058039 127041620 ppf: 94 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Agreement between manual relaxometry and semi-automated scanner-based multi-echo Dixon technique for measuring liver T2* in a pediatric and young adult population. aug: au: Serai, Suraj D. Smith, Ethan A. Trout, Andrew T. Dillman, Jonathan R. affil: Department of Radiology, MLC 5031, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave., 45229, Cincinnati, OH, USA sug: subj: Magnetic Resonance Imaging Methods Iron Overload Liver Child, Preschool Female Adult Adolescence Infant Child Imaging, Three-Dimensional Reproducibility of Results Male Human Child, Preschool: 2-5 years Adult: 19-44 years Adolescent: 13-18 years Infant: 1-23 months Child: 6-12 years Female Male ab: Background: Commercially available 3D multi-echo Dixon (mDixon) sequences provide parametric maps of liver T2*, obviating manual curve fitting that is often required with conventional gradient recalled echo (GRE)-based multi-echo relaxometry, potentially simplifying clinical work flow.Objective: The purpose of our study was to compare T2* values generated by a 3D mDixon sequence to values generated by GRE-based T2* relaxometry with manual curve fitting in a pediatric and young adult population.Materials and Methods: We reviewed clinical MRI exams performed at 1.5T for liver iron content estimation between February 2015 and June 2016 that included both mDixon and multi-echo GRE pulse sequences. We obtained mean T2* measurements based on each sequence by drawing regions of interest on each of four axial slices through the mid-liver. We compared mDixon-based and GRE-based T2* measurements using paired t-tests and assessed agreement using single-measure intra-class correlation coefficients and Bland-Altman difference plots.Results: One hundred nine patients met inclusion criteria (site 1=82; site 2=27). Mean age was 12.4±5.8 years, and 42 subjects (39%) were female. There was no statistically significant difference in mean T2* values for the two sequences (pooled means: 11.7±11.0 [GRE] vs. 11.7±10.9 ms [mDixon]; P=0.93). There was excellent absolute agreement between sequences (intraclass correlation coefficient [ICC]=0.98 for patients at both sites, confidence interval [CI]: 0.97-0.98 with mean bias of 0.0 ms [-4.2 ms to +4.2 ms]).Conclusion: 3D mDixon is accurate for measuring liver T2* and can likely replace 2D GRE-based relaxometry. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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