The international normalized ratio (INR): What reagent, what instrument? The assessment of the agreement between INR values according to different reagent/instrument combinations.
What is known and objective The international normalized ratio ( INR) is widely used to monitor patients on vitamin K antagonists. This study aimed to assess the agreement of INR values obtained with different thromboplastin/instrument combinations. Material and methods International normalized rati...
| Published in: | Journal of Clinical Pharmacy & Therapeutics Vol. 43; no. 1; pp. 52 - 59 |
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| Main Authors: | , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Feb2018
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127063631&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127063631 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Feb2018 vid: 43 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 127063631 127063631 127063631 10.1111/jcpt.12608 127063631 ppf: 52 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The international normalized ratio (INR): What reagent, what instrument? The assessment of the agreement between INR values according to different reagent/instrument combinations. aug: au: Baccouche, H. Chakroun, A. Zoghlami, A. Mahjoub, S. Ben Romdhane, N. affil: Hematology Department, Faculty of Medicine of Tunis, Rabta Hospital, Tunis University El Manar, Tunis, Tunisia sug: subj: International Normalized Ratio Evaluation Indicators and Reagents Blood Coagulation Classification Vitamin K Antagonists and Inhibitors Prothrombin Time Thromboplastin Human Sample Size Calibration kappa Statistic ab: What is known and objective The international normalized ratio ( INR) is widely used to monitor patients on vitamin K antagonists. This study aimed to assess the agreement of INR values obtained with different thromboplastin/instrument combinations. Material and methods International normalized ratio was determined on plasmas from 330 patients undergoing antivitamin K treatment (with acenocoumarol), using two calibration methods and four reagent/instrument combinations: Both Neoplastine CI and Neoplastine CI Plus on STA-R instrument from Diagnostica STAGO, Asnières, France; and both Thromborel S and Innovin on SYSMEX 2100i instrument from Siemens Health Care Diagnostics, Marbung, Germany. The agreement analysis was done using the Bland-Altman plot and the Cohen Kappa coefficient. Results The mean of the differences between the INR values and the limits of agreement were −0.07 [−0.51 to 0.38] for the Neoplastine CI plus and Neoplastine CI reagents, −0.08 [−1.18 to 1.03] for the Thromborel S and Innovin reagents when the INR was calculated, −0.1 [−1.15 to 0.95] for the Thromborel S and Innovin reagents when the INR was directly calibrated and −0.1 [−0.7 to 0.5] for the Neoplastine CI plus and Thromborel S. Cohen's kappa coefficients were 0.94, 0.76, 0.85 and 0.82, respectively. New findings and conclusion The agreement between the four reagent/instrument combinations was high enough to classify patients as inefficaciously or efficaciously anticoagulated. The data interpretation should always be related to the clinical purpose. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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