Characteristics of False-Negative Thyroid Fine-Needle Aspirates.
Introduction: False-negative thyroid fine-needle aspirates (FNA) are not well characterized. Methods: We correlated the results of all thyroid aspirations from 1997 to 2016 with histologic follow-up. Results: There were 13,733 aspirates, 2,112 (15.3%) resections, and 678 malignancies (32.1%). Eighte...
| Publicado en: | Acta Cytologica Vol. 62; no. 1; pp. 12 - 19 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Karger AG
Jan2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127169983&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127169983 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00015547 10OE jtl: Acta Cytologica issn: 00015547 maglogo: N pubinfo: dt: Jan2018 vid: 62 iid: 1 pid: 2485 pub: Karger AG artinfo: ui: 127169983 10.1159/000481722 127169983 ppf: 12 ppct: 7 formats: tig: atl: Characteristics of False-Negative Thyroid Fine-Needle Aspirates. aug: au: Renshaw, Andrew A. Gould, Edwin W. affil: Department of Pathology, Baptist Hospital of Miami and Miami Cancer Institute, Miami, FL, USA sug: ab: Introduction: False-negative thyroid fine-needle aspirates (FNA) are not well characterized. Methods: We correlated the results of all thyroid aspirations from 1997 to 2016 with histologic follow-up. Results: There were 13,733 aspirates, 2,112 (15.3%) resections, and 678 malignancies (32.1%). Eighteen (2.7%) false-negative cases were identified (interpretation, n = 6; sampling, n = 7; and new nodules, n = 5). Interpretive false-negative cases were significantly less likely when the indeterminate rate was greater than 13% (p = 0.01). Interpretive errors involved rare cells with poorly developed features of malignancy. Sampling errors were not associated with scant cellularity in the specimen. The majority of false-negative cases were not resected because of a clinical suspicion of malignancy. The sensitivity of FNA for 9-mm papillary carcinomas was 44.3%. Conclusion: In this cohort, the false-negative rate of thyroid FNA was 2.7% and the risk of malignancy for a benign diagnosis was 3.5%. Interpretative errors involved rare cells with poorly developed features of malignancy. There is little evidence that either the false-negative rate or the risk of malignancy of a benign thyroid FNA is different in patients who do and do not undergo resection. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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