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Evidence for regional hippocampal damage in patients with schizophrenia.

Purpose: Schizophrenia patients show cognitive and mood impairments, including memory loss and depression, suggesting damage in the brain regions. The hippocampus is a brain structure that is significantly involved in memory and mood function and shows impairment in schizophrenia. In the present stu...

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Published in:Neuroradiology Vol. 60; no. 2; pp. 199 - 206
Main Authors: Singh, Sadhana, Khushu, Subash, Kumar, Pawan, Goyal, Satnam, Bhatia, Triptish, Deshpande, Smita N
Format: diagnostic images research tables/charts Journal Article
Published: Springer Nature Feb2018
Online Access:View this record in EBSCOhost
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      dt: Feb2018
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      pub: Springer Nature
      place: New York, New York
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        127193936
        127193936
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        127193936
        10.1007/s00234-017-1954-4
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      tig:
        atl: Evidence for regional hippocampal damage in patients with schizophrenia.
      aug:
        au:
          Singh, Sadhana
          Khushu, Subash
          Kumar, Pawan
          Goyal, Satnam
          Bhatia, Triptish
          Deshpande, Smita N
        affil: NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, Lucknow Road, Timarpur, Delhi, India
      sug:
        subj:
          Hippocampus Pathology
          Schizophrenia Pathology
          Magnetic Resonance Imaging Methods
          Proton Magnetic Resonance Spectroscopy
          Human India
          Hippocampus Analysis
          Gray Matter Pathology
          Glutamic Acid Analysis
          Inositol Analysis
          Descriptive Statistics
      ab: Purpose: Schizophrenia patients show cognitive and mood impairments, including memory loss and depression, suggesting damage in the brain regions. The hippocampus is a brain structure that is significantly involved in memory and mood function and shows impairment in schizophrenia. In the present study, we examined the regional hippocampal changes in schizophrenia patients using voxel-based morphometry (VBM), Freesurfer, and proton magnetic resonance spectroscopy (H MRS) procedures. Methods: H MRS and high-resolution T1-weighted magnetic resonance imaging were collected in both healthy control subjects ( N = 28) and schizophrenia patients ( N = 28) using 3-Tesla whole body MRI system. Regional hippocampal volume was analyzed using VBM and Freesufer procedures. The relative ratios of the neurometabolites were calculated using linear combination model (LCModel). Results: Compared to controls, schizophrenia patients showed significantly decreased gray matter volume in the hippocampus. Schizophrenia patients also showed significantly reduced glutamate (Glu) and myo-inositol (mI) ratios in the hippocampus. Additionally, significant positive correlation between gray matter volume and Glu/tCr was also observed in the hippocampus in schizophrenia. Conclusion: Our findings provide an evidence for a possible association between structural deficits and metabolic alterations in schizophrenia patients.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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