Risk of developing pyoderma gangrenosum after procedures in patients with a known history of pyoderma gangrenosum-A retrospective analysis.
Background: The risk of postoperative pyoderma gangrenosum (PG) in patients with a known history of PG is unknown.Objective: To quantify risk and identify patient- and/or procedure-related risk factors for postsurgical recurrence or exacerbation of PG in patients with a known history of PG.Methods:...
| Publicado en: | Journal of the American Academy of Dermatology Vol. 78; no. 2; pp. 310 - 311 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Feb2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127284692&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127284692 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01909622 1ZF jtl: Journal of the American Academy of Dermatology issn: 01909622 maglogo: N pubinfo: dt: Feb2018 vid: 78 iid: 2 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 127284692 127284692 NLM28947285 127284692 10.1016/j.jaad.2017.09.040 NLM28947285 127284692 ppf: 310 ppct: 1 formats: tig: atl: Risk of developing pyoderma gangrenosum after procedures in patients with a known history of pyoderma gangrenosum-A retrospective analysis. aug: au: Xia, Fan Di Liu, Kristina Lockwood, Stephen Butler, Daniel Tsiaras, William G. Joyce, Cara Mostaghimi, Arash affil: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts sug: subj: Pyoderma Gangrenosum Epidemiology Postoperative Complications Epidemiology Surgery, Operative Statistics and Numerical Data Odds Ratio Female Retrospective Design Massachusetts Middle Age Disease Progression Biopsy Statistics and Numerical Data Risk Factors Microsurgery Statistics and Numerical Data Male Recurrence Human Middle Aged: 45-64 years Female Male ab: Background: The risk of postoperative pyoderma gangrenosum (PG) in patients with a known history of PG is unknown.Objective: To quantify risk and identify patient- and/or procedure-related risk factors for postsurgical recurrence or exacerbation of PG in patients with a known history of PG.Methods: We retrospectively evaluated the likelihood of postsurgical recurrence or exacerbation of PG for all patients with a confirmed diagnosis of PG at Brigham and Women's Hospital and Massachusetts General Hospital from 2000 to 2015.Results: In all, 5.5% of procedures (n = 33) led to recurrence of PG in 15.1% of patients (n = 25). Compared with skin biopsy, small open surgical procedures had an adjusted odds ratio (aOR) of 8.65 (95% confidence interval [CI], 1.55-48.33) for PG recurrence or exacerbation; large open surgical procedures had an aOR of 5.97 (95% CI, 1.70-21.00); and Mohs micrographic surgery/skin excision had an aOR of 6.47 (95% CI, 1.77-23.61). PG chronically present at the time of the procedure had an aOR of 4.58 (95% CI, 1.72-12.22). Immunosuppression, time elapsed since the original PG diagnosis, and procedure location did not significantly influence risk.Limitations: Our study is limited by its retrospective nature and relatively small sample size.Conclusion: There is a small but clinically meaningful risk for postsurgical recurrence or exacerbation of PG in patients with a known history of PG; higher risks occur with more invasive procedures and chronically present PG. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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