Spike densities of the amygdala and neocortex reflect progression of kindled motor seizures.
Amygdala kindling is a common temporal lobe-like seizure model. In the present study, temporal and spectral analyses of the ictal period were investigated throughout amygdala kindling in response to different behavioral seizures. Right-side amygdala was kindled to induce epileptiform afterdischarges...
| Published in: | Medical & Biological Engineering & Computing Vol. 56; no. 1; pp. 99 - 113 |
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| Main Authors: | , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Jan2018
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127330162&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127330162 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Jan2018 vid: 56 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 127330162 127330162 144000525 NLM28674781 127330162 10.1007/s11517-017-1672-4 NLM28674781 127330162 ppf: 99 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Spike densities of the amygdala and neocortex reflect progression of kindled motor seizures. aug: au: Wang, Yu-Lin Liang, Sheng-Fu Su, Alvin W. Y. Shaw, Fu-Zen affil: Department of Computer Science Information Engineering, National Cheng Kung University, Tainan, Taiwan sug: subj: Action Potentials Physiology Basal Ganglia Physiopathology Seizures Physiopathology Neocortex Physiopathology Nervous System Physiology Physiology Rats Time Factors Animals Behavior, Animal Male Funding Source Animal Studies Male ab: Amygdala kindling is a common temporal lobe-like seizure model. In the present study, temporal and spectral analyses of the ictal period were investigated throughout amygdala kindling in response to different behavioral seizures. Right-side amygdala was kindled to induce epileptiform afterdischarges (ADs). ADs of both the frontal cortex and amygdala were analyzed. Powers of the low (0-9 Hz)- and high (12-30 Hz)-frequency bands in response to different behavioral seizures were calculated. Densities of upward and downward peaks of spikes, which reflected information of spike count and spike pattern, throughout kindle-induced ADs were calculated. Progression was seen in the temporal and spectral characteristics of amygdala-kindled ADs in response to behaviors. Numbers of significant differences of all 1-s AD segments between two Racine's seizure stages were significantly higher in upward and downward indexes of the temporal spike than those using the spectral method in both the amygdala and neocortex. Ability for distinguishing seizure stages was significantly higher in temporal spike density of amygdala ADs compared to those of frontal ADs. Our results showed that amygdala kindling caused spectrotemporal changes of activities in the amygdala and frontal cortex. The density of spike-related peaks had better distinguishability in response to behavioral seizures, particularly in a seizure zone of amygdala. The present study provides a new temporal index of spike's peak density to understand progression of motor seizures in the kindling process. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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