Oxygenation Status in Chronic Leg Ulcer After Topical Hemoglobin Application May Act as a Surrogate Marker to Find the Best Treatment Strategy and to Avoid Ineffective Conservative Long-term Therapy.
Purpose: Chronic leg ulcers can be a challenge to treat and long-term therapy a significant cost factor in western public health budgets. Objective wound assessment assays enabling selection of appropriate wound therapy regimes would be desirable. Oxygenation status in ulcer tissue has obtained incr...
| Publicado en: | Molecular Imaging & Biology Vol. 20; no. 1; pp. 124 - 131 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | clinical trial pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127460424&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127460424 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Feb2018 vid: 20 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 127460424 127460424 143968392 NLM28702902 127460424 10.1007/s11307-017-1103-9 NLM28702902 127460424 ppf: 124 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Oxygenation Status in Chronic Leg Ulcer After Topical Hemoglobin Application May Act as a Surrogate Marker to Find the Best Treatment Strategy and to Avoid Ineffective Conservative Long-term Therapy. aug: au: Petri, Maximilian Stoffels, Ingo Griewank, Klaus Jose, Jithin Engels, Peter Schulz, Andrea Pötzschke, Harald Jansen, Philipp Schadendorf, Dirk Dissemond, Joachim Klode, Joachim affil: Department of Dermatology, Venerology and Allergology, University-Hospital Essen, University of Duisburg-Essen, Essen, Germany sug: subj: Hemoglobins Administration and Dosage Leg Ulcer Drug Therapy Oxygen Metabolism Hemoglobins Therapeutic Use Adult Human Acoustics Female Administration, Topical Aged, 80 and Over Aged Chronic Disease Male Carboxyhemoglobin Metabolism Middle Age Wound Healing Biopsy Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Trials Adult: 19-44 years Aged, 80 & over Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Purpose: Chronic leg ulcers can be a challenge to treat and long-term therapy a significant cost factor in western public health budgets. Objective wound assessment assays enabling selection of appropriate wound therapy regimes would be desirable. Oxygenation status in ulcer tissue has obtained increased attention as a relevant factor in wound healing. To increase oxygenation in wounds, a topical hemoglobin spray was developed. Although favorable results have been noted, the link between clinical efficacy and the mode of action has not been demonstrated. The aims were to determine if changes in tissue oxygenation can be measured after topical application of hemoglobin on chronic wounds and to evaluate the findings in terms of therapy strategies.Procedures: Photoacoustic imaging was used to measure the local oxygen saturation (StO2) in leg ulcers before and after hemoglobin spray treatment. Sclerosis of the leg ulcers was histopathologically graded and the change in wound size was documented in a follow-up examination.Results: Measuring 49 patients, an increase in StO2 after topical hemoglobin application from on average 66.1 to 71 % (p = 0.017) after 20 min was observed. Depending on the increase in StO2 (>10 % or <10 %) patients were stratified into a Responder and a Non-Responder group. Wound size significantly decreased in the Responder Group (p = 0.001), while no significant difference in the Non-Responder group (p = 0.950) was noted.Conclusion: Our findings suggest that the likelihood of wound healing under conservative therapy can be predicted by measuring changes in StO2 after topical hemoglobin application. This assay may reduce treatment time and costs by avoiding ineffective conservative long-term therapy.Trial Registration: German Clinical Trials Register: DRKS00005993. pubtype: Academic Journal doctype: clinical trial pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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