Physical Function in Subjects Requiring Extracorporeal Membrane Oxygenation Before or After Lung Transplantation.
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is used as a rescue therapy before and after lung transplantation, but little is known about functional recovery or complications after ECMO in this cohort. This study aimed to describe early physical function and leg complications in subjects w...
| Publicado en: | Respiratory Care Vol. 63; no. 2; pp. 194 - 203 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Feb2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127544999&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127544999 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Feb2018 vid: 63 iid: 2 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 127544999 127544999 127544999 10.4187/respcare.05334 127544999 ppf: 194 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Physical Function in Subjects Requiring Extracorporeal Membrane Oxygenation Before or After Lung Transplantation. aug: au: Hayes, Kate Hodgson, Carol L. Pellegrino, Vincent A. Snell, Greg Tarrant, Benjamin Fuller, Louise M. Holland, Anne E. affil: Department of Physiotherapy, The Alfred Hospital, Melbourne, Victoria, Australia sug: subj: Extracorporeal Membrane Oxygenation Lung Transplantation Human Retrospective Design Adult Middle Age Male Female Rehabilitation Quality of Life Time Factors Data Analysis Software Paired T-Tests Mann-Whitney U Test Chi Square Test Fisher's Exact Test Wilcoxon Rank Sum Test Nonparametric Statistics Multiple Linear Regression Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is used as a rescue therapy before and after lung transplantation, but little is known about functional recovery or complications after ECMO in this cohort. This study aimed to describe early physical function and leg complications in subjects who received ECMO before or after lung transplantation, and to compare functional outcomes to a matched cohort of subjects who did not require ECMO. METHODS: A retrospective study was conducted over 2 years. Highest mobility level was assessed, in both the ECMO and non-ECMO groups, prior to ICU admission, at ICU discharge, and at hospital discharge, while 6-min walk distance was measured at hospital discharge and at 3 months. Strength was assessed at ICU discharge and at hospital discharge in the ECMO subjects only, and leg complications were recorded up until hospital discharge. RESULTS: 17 subjects (mean age 43±13 y; 65% (11 of 17 subjects) female) required ECMO before or after lung transplant. Survival to hospital discharge was 82% (14 of 17 subjects). At ICU discharge, strength and mobility levels were poor, but both improved by hospital discharge (P < .001). Leg complications were reported in 50% of survivors (7 of 14 subjects). ECMO survivors spent longer in the ICU (P < .001) and hospital (P = .002) and had worse physical function (ie, lower mobility level at ICU discharge, mean difference -1, P = .02; 6-min walk distance at hospital discharge: mean difference -99 m, P = .004) than lung transplant recipients not requiring ECMO (n = 28). CONCLUSIONS: In subjects requiring ECMO before or after lung transplantation, 82% survived to hospital discharge, but leg complications were common and physical function was poor at ICU discharge. Physical function improved over time, however subjects who required ECMO had a longer period of hospitalization and worse physical function at ICU and hospital discharge than those who did not require ECMO. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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