Long non-coding RNA GHET1 Is Possibly Involved in the Pathogenesis of a Fraction of Breast Cancers.
Background: Breast cancer is the most frequently diagnosed cancer among women. Although several targeted therapies have been applied for patients with breast cancer, due to its heterogeneous nature, several patients do not benefit from these treatment modalities. Consequently, it is necessary to ide...
| Published in: | International Journal of Cancer Management Vol. 10; no. 10; pp. 1 - 6 |
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| Main Authors: | , , , , |
| Format: | research tables/charts Journal Article |
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Medical Journals Commission of the Ministry of Health & Medical Education
Oct2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127613621&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127613621 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 25384422 L6AI jtl: International Journal of Cancer Management issn: 25384422 maglogo: N pubinfo: dt: Oct2017 vid: 10 iid: 10 pid: 66482 pub: Medical Journals Commission of the Ministry of Health & Medical Education artinfo: ui: 127613621 127613621 127613621 10.5812/ijcm.9920 127613621 ppf: 1 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Long non-coding RNA GHET1 Is Possibly Involved in the Pathogenesis of a Fraction of Breast Cancers. aug: au: Sarrafzadeh, Shaghayegh Taheri, Mohammad Geranpayeh, Lobat Ghafouri-Fard, Somayyeh Ghafouri-Fard, Soudeh affil: Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Breast Neoplasms Familial and Genetic Gene Expression Human Iran Carcinoma, Ductal, Breast Familial and Genetic Polymerase Chain Reaction Methods Body Mass Index Receptors, Estrogen Receptors, Progesterone Neoplasm Staging Neoplasm Grading Neoplasm Invasiveness Familial and Genetic Prospective Studies Cancer Patients ab: Background: Breast cancer is the most frequently diagnosed cancer among women. Although several targeted therapies have been applied for patients with breast cancer, due to its heterogeneous nature, several patients do not benefit from these treatment modalities. Consequently, it is necessary to identify novel markers, which participate in the development of breast cancer. Recently, long non-coding RNAs (IncRNAs) have gained attention in this regard. Among them is IncRNA-gastric carcinoma high expressed transcript 1 (IncRNA-GHET1), whose participation in gastric and bladder cancers have been identified. Objectives: In the present study, we aimed at identifying lncRNA-GHET1 expression in breast cancer tissues compared with their adjacent non-cancerous tissues (ANCT) in a cohort of Iranian patients. Methods: We evaluated the expression of GHET1 in 47 samples of invasive ductal carcinoma of breast in comparison with their ANCTs by means of quantitative real time-PCR. Results: GHET1 has been shown to be up-regulated in 26% (13 out of 47) breast tumor samples compared with their paired ANCTs. Transcript levels of GHET1 were shown to be associated with body mass index. No other significant association was found between the level of transcripts and patients' clinical data, such as estrogen receptor, progesterone receptor, Her2/neu status, tumor stage or grade. Conclusions: GHET1 is possibly contributed in the pathogenesis of a fraction of breast cancers pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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