Effects of L-Arginine Supplementation on Leukogram, Inflammatory Bowel Infiltrates and Immunoglobulins with 5-FU Use in Rats.
This study evaluated the effects of L-arginine supplementation on blood parameters, kidney and liver function, immunoglobulins and noninflammatory infiltrates in the small intestines of rats subjected to chemotherapy with 5-fluorouracil (5-FU). Thirty-two Wistar rats were randomly distributed into 4...
| Publicado en: | Nutrition & Cancer Vol. 70; no. 2; pp. 249 - 257 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Feb/Mar2018
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127727766&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127727766 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: Feb/Mar2018 vid: 70 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 127727766 127727766 127727766 10.1080/01635581.2018.1424346 127727766 ppf: 249 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of L-Arginine Supplementation on Leukogram, Inflammatory Bowel Infiltrates and Immunoglobulins with 5-FU Use in Rats. aug: au: Balmant, Bianca D. Araújo, Eloisa O. N. Yabuki, Denise Novais, Amanda B. Genaro, Sandra C. Laposy, Cecilia B. Goiozo, Paulo F. I. Chacur, Marcelo G. M. Giuffrida, Rogério Reis, Luis S. L. S. affil: Postgraduate Program in Animal Science, UNOESTE, Presidente Prudente, Sao Paulo, Brasil sug: subj: Arginine Pharmacodynamics Fluorouracil Administration and Dosage Blood Physiology Drug Effects Kidney Physiology Liver Physiology Immunoglobulins Metabolism Intestine, Small Drug Effects Animal Studies Rats In Vivo Studies Neutrophils Analysis Platelet Count Immunoglobulins Blood Fibrinogen Blood Dietary Supplementation Thrombocytopenia Prevention and Control Mucositis, Gastrointestinal Prevention and Control ab: This study evaluated the effects of L-arginine supplementation on blood parameters, kidney and liver function, immunoglobulins and noninflammatory infiltrates in the small intestines of rats subjected to chemotherapy with 5-fluorouracil (5-FU). Thirty-two Wistar rats were randomly distributed into 4 groups (8 rats/group): an untreated control group, and test groups receiving one dose of 5-FU (G5-FUgroup), one dose of 5-FU and 295 mg L-arginine/day (GArg295group) or one dose of 5-FU and 458 mg L-arginine/day (GArg458group). Neutrophil count, platelet count, serum IgA, and fibrinogen levels in GArg295and GArg458remained within normal limits after chemotherapy. In addition, in GArg458the inflammatory bowel infiltrates improved in 57% of the rats, which showed mild inflammation. The results suggest that daily supplementation with 295 or 458 mg L-arginine attenuates the side effects of 5-FU, including thrombocytopenia and neutropenia, and modulates IgA production. Supplementation with 458 mg of L-arginine/day can also reduce mucositis levels in the small intestine after 5-FU chemotherapy. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|