Drug-Induced Pyoderma Gangrenosum: A Review.
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that may be caused by an adverse drug reaction. We discuss the clinical presentation and outcomes of 52 cases of drug-induced PG reported to date in the literature. We conducted our literature search for case reports of drug-induced PG usin...
| Publicado en: | American Journal of Clinical Dermatology Vol. 19; no. 1; pp. 67 - 78 |
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| Autores principales: | , , , , |
| Formato: | questionnaire/scale research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127794848&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127794848 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11750561 C4Q jtl: American Journal of Clinical Dermatology issn: 11750561 maglogo: N pubinfo: dt: Feb2018 vid: 19 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 127794848 127794848 143956902 127794848 10.1007/s40257-017-0308-7 127794848 ppf: 67 ppct: 11 formats: tig: atl: Drug-Induced Pyoderma Gangrenosum: A Review. aug: au: Wang, Jane Y. French, Lars E. Shear, Neil H. Amiri, Afkham Alavi, Afsaneh affil: Faculty of Medicine, University of Toronto, Toronto, ON, Canada sug: subj: Pyoderma Gangrenosum Chemically Induced Human Systematic Review PubMed Medline Embase Cocaine Adverse Effects Isotretinoin Adverse Effects Propylthiouracil Adverse Effects Tyrosine Kinase Inhibitors Adverse Effects Adverse Drug Event Scales ab: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that may be caused by an adverse drug reaction. We discuss the clinical presentation and outcomes of 52 cases of drug-induced PG reported to date in the literature. We conducted our literature search for case reports of drug-induced PG using keywords on PubMed and Medical Subject Heading (MeSH) terms on MEDLINE and EMBASE. To assess the probability that each case of PG was related to drug therapy, we used the Naranjo criteria. We identified 44 studies in the literature, with a total of 52 cases of drug-induced PG. The mean Naranjo score for cocaine-induced PG (<italic>n</italic> = 13) was 9.4, indicating a definite adverse drug reaction, while the mean Naranjo scores for isotretinoin (<italic>n</italic> = 5), propylthiouracil (<italic>n</italic> = 5), and sunitinib (<italic>n</italic> = 5) were 6.2, 6.8, and 7.4, respectively, indicating probable adverse drug reactions. Drugs should be considered as a possible triggering event whenever PG is diagnosed, and clinicians should particularly consider this in patients taking isotretinoin, propylthiouracil, or sunitinib, as well as in patients with a history of cocaine use. pubtype: Academic Journal doctype: questionnaire/scale research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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