HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors.
Background: Approximately one in five breast cancers are driven by amplification and overexpression of the human epidermal growth factor receptor 2 (HER2) receptor kinase, and HER2-enriched (HER2E) is one of four major transcriptional subtypes of breast cancer. We set out to understand the genomics...
| Publicado en: | Breast Cancer Research Vol. 20; pp. 1 - 17 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
1/30/2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127797242&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127797242 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14655411 8UYJ jtl: Breast Cancer Research issn: 14655411 maglogo: N pubinfo: dt: 1/30/2018 vid: 20 pid: 24147 pub: BioMed Central artinfo: ui: 127797242 127797242 NLM29382369 10.1186/s13058-018-0933-y NLM29382369 127797242 ppf: 1 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors. aug: au: Daemen, Anneleen Manning, Gerard affil: Bioinformatics & Computational Biology, Genentech, Inc, 1 DNA Way, MS444a, 94080, South San Francisco, CA, USA sug: subj: Proteins Receptors, Cell Surface Breast Neoplasms Neoplastic Processes Receptors, Cell Surface Antagonists and Inhibitors Proteins Antagonists and Inhibitors Genes Breast Neoplasms Drug Therapy Breast Neoplasms Classification Female Breast Neoplasms Pathology Female ab: Background: Approximately one in five breast cancers are driven by amplification and overexpression of the human epidermal growth factor receptor 2 (HER2) receptor kinase, and HER2-enriched (HER2E) is one of four major transcriptional subtypes of breast cancer. We set out to understand the genomics of HER2 amplification independent of subtype, and the underlying drivers and biology of HER2E tumors.Methods: We investigated published genomic data from 3155 breast tumors and 5391 non-breast tumors.Results: HER2 amplification is a distinct driver event seen in all breast cancer subtypes, rather than a subtype marker, with major characteristics restricted to amplification and overexpression of HER2 and neighboring genes. The HER2E subtype has a distinctive transcriptional landscape independent of HER2A that reflects androgen receptor signaling as replacement for estrogen receptor (ER)-driven tumorigenesis. HER2 amplification is also an event in 1.8% of non-breast tumors.Conclusions: These discoveries reveal therapeutic opportunities for combining anti-HER2 therapy with anti-androgen agents in breast cancer, and highlight the potential for broader therapeutic use of HER2 inhibitors. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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