Functional Synthetic Model for the Lanthanide-Dependent Quinoid Alcohol Dehydrogenase Active Site.
The oxidation of methanol by dehydrogen-ase enzymes is an essential part of the bacterial methane metabolism cycle. The recent discovery of a lanthanide (Ln) cation in the active site of the XoxF dehydrogenase represents the only example of a rare-earth element in a physiological role. Herein, we re...
| Publicado en: | Journal of the American Chemical Society Vol. 140; no. 4; pp. 1223 - 1227 |
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| Autores principales: | , , , |
| Formato: | Artículo |
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American Chemical Society
1/31/2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=127797900&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 127797900 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 1/31/2018 vid: 140 iid: 4 pid: 997 pub: American Chemical Society artinfo: ui: 127797900 10.1021/jacs.7b12318 ppf: 1223 ppct: 4 formats: tig: atl: Functional Synthetic Model for the Lanthanide-Dependent Quinoid Alcohol Dehydrogenase Active Site. aug: au: McSkimming, Alex Cheisson, Thibault Carroll, Patrick J. Schelter, Eric J. affil: P. Roy and Diana T. Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 S 34th Street, Philadelphia, Pennsylvania 19104, United States su: Quinoidine Catalytic dehydrogenation Density functional theory Alcohol dehydrogenase Oxidation of methanol sug: subj: Quinoidine Catalytic dehydrogenation Density functional theory Alcohol dehydrogenase Oxidation of methanol ab: The oxidation of methanol by dehydrogen-ase enzymes is an essential part of the bacterial methane metabolism cycle. The recent discovery of a lanthanide (Ln) cation in the active site of the XoxF dehydrogenase represents the only example of a rare-earth element in a physiological role. Herein, we report the first synthetic, functional model of Ln-dependent dehydrogenase and its stoichiometric and catalytic dehydrogenation of a benzyl alcohol. Density functional theory calculations implicate a hydride transfer mechanism for these reactions. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2018 holdings: @attributes: islocal: N |
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