Hyperammonemia associated with distal renal tubular acidosis or urinary tract infection: a systematic review.
Background: Hyperammonemia usually results from an inborn error of metabolism or from an advanced liver disease. Individual case reports suggest that both distal renal tubular acidosis and urinary tract infection may also result in hyperammonemia.Methods: A systematic review of the literature on hyp...
| Publicado en: | Pediatric Nephrology Vol. 33; no. 3; pp. 485 - 492 |
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| Autores principales: | , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127817578&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127817578 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Mar2018 vid: 33 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 127817578 127817578 143971923 127817578 10.1007/s00467-017-3829-7 127817578 ppf: 485 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Hyperammonemia associated with distal renal tubular acidosis or urinary tract infection: a systematic review. aug: au: Clericetti, Caterina M. Milani, Gregorio P. Lava, Sebastiano A. G. Bianchetti, Mario G. Simonetti, Giacomo D. Giannini, Olivier affil: Pediatric Department of Southern Switzerland, Bellinzona, Switzerland sug: subj: Hypoaldosteronism Etiology Metabolic Diseases Complications Systematic Review Human Urinary Tract Infections Hyperparathyroidism Ammonia Blood Bicarbonates Blood Anorexia Metabolic Diseases In Infancy and Childhood Metabolic Diseases In Adulthood Child Adult Child: 6-12 years Adult: 19-44 years ab: Background: Hyperammonemia usually results from an inborn error of metabolism or from an advanced liver disease. Individual case reports suggest that both distal renal tubular acidosis and urinary tract infection may also result in hyperammonemia.Methods: A systematic review of the literature on hyperammonemia secondary to distal renal tubular acidosis and urinary tract infection was conducted.Results: We identified 39 reports on distal renal tubular acidosis or urinary tract infections in association with hyperammonemia published between 1980 and 2017. Hyperammonemia was detected in 13 children with distal renal tubular acidosis and in one adult patient with distal renal tubular acidosis secondary to primary hyperparathyroidism. In these patients a negative relationship was observed between circulating ammonia and bicarbonate levels (<italic>P</italic> < 0.05). In 31 patients (19 children, 12 adults), an acute urinary tract infection was complicated by acute hyperammonemia and symptoms and signs of acute neuronal dysfunction, such as an altered level of consciousness, convulsions and asterixis, often associated with signs of brain edema, such as anorexia and vomiting. Urea-splitting bacteria were isolated in 28 of the 31 cases. The urinary tract was anatomically or functionally abnormal in 30 of these patients.Conclusions: This study reveals that both altered distal renal tubular acidification and urinary tract infection may be associated with relevant hyperammonemia in both children and adults. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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