TGF-α Overexpression in Breast Cancer Bone Metastasis and Primary Lesions and TGF-α Enhancement of Expression of Procancer Metastasis Cytokines in Bone Marrow Mesenchymal Stem Cells.
Bone metastasis (BM) is the advanced complication of breast cancer, while bone marrow-derived mesenchymal stem cells (BMSCs) in the microenvironment unclearly contribute to cancer metastasis. This study investigated potential roles of transforming growth factor- (TGF-) <italic>α</italic> in the inte...
| Publicado en: | BioMed Research International Vol. 2018; pp. 1 - 11 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2/8/2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127888944&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127888944 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2/8/2018 vid: 2018 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 127888944 127888944 127888944 10.1155/2018/6565393 127888944 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: TGF-α Overexpression in Breast Cancer Bone Metastasis and Primary Lesions and TGF-α Enhancement of Expression of Procancer Metastasis Cytokines in Bone Marrow Mesenchymal Stem Cells. aug: au: Sun, Jingbo Cui, Haiyan Gao, Yanxin Pan, Yangjian Zhou, Kun Huang, Jingzhan Lan, Jin Wei, Qingzhu Liu, Xiaolong Liu, Lixin Xian, Cory J. affil: Department of General Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China sug: subj: Cytokines Gene Expression Breast Neoplasms Bone Metastases Bone Marrow Stem Cells Neoplasm Metastasis Neoplasms, Fibrous Tissue Retrospective Design Macrophages Neoplastic Processes Human Interleukins Vascular Endothelial Growth Factors Growth Substances ab: Bone metastasis (BM) is the advanced complication of breast cancer, while bone marrow-derived mesenchymal stem cells (BMSCs) in the microenvironment unclearly contribute to cancer metastasis. This study investigated potential roles of transforming growth factor- (TGF-) <italic>α</italic> in the interaction between breast cancer and BMSCs in BM. Clinical cases of breast cancer with bone metastasis (BMBC), breast cancer without bone metastasis (Non-BM-BC), and benign fibroadenoma (Benign) were enlisted in a retrospective study. TGF-<italic>α</italic> was found obviously overexpressed in BM lesion of BMBC compared to primary lesion of both BMBC and Non-BM-BC (P<0.01), and TGF-<italic>α</italic> was higher in primary lesion of both BMBC and Non-BM-BC (P<0.01) than Benign group. Interestingly, TGF-<italic>α</italic> in nontumor tissues of both BMBC and Non-BM-BC was at a higher level than Benign group (P<0.01), and numbers of macrophages in nontumor tissues of both BMBC and Non-BM-BC (P<0.01) were higher than Benign group. Furthermore, in cultured human BMSCs, TGF-<italic>α</italic> stimulated production of procancer cytokines including IL-6, VEGF, FGF10, FGF17, and TGF-<italic>β</italic>1 in a dose-dependent manner. Thus, TGF-<italic>α</italic> in BC could potentially be an important signal of carcinogenesis and metastasis. Macrophages in the nontumor tissue of BC may not be protective but could promote cancer metastasis. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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