A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age.
Objective: To evaluate for the first time the effects of a combination of sage, rosemary and melissa (Salvia officinalis L., Rosmarinus officinalis L. and Melissa officinalis L.; SRM), traditional European medicines, on verbal recall in normal healthy subjects. To devise a suitable study design for...
| Publicado en: | Phytomedicine Vol. 39; pp. 42 - 49 |
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| Autores principales: | , , , , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Elsevier GmbH, Urban & Fischer Verlag
Jan2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127922770&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127922770 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09447113 NXH jtl: Phytomedicine issn: 09447113 maglogo: N pubinfo: dt: Jan2018 vid: 39 pid: 24997 pub: Elsevier GmbH, Urban & Fischer Verlag place: London, <Blank> artinfo: ui: 127922770 127922770 NLM29433682 127922770 10.1016/j.phymed.2017.08.015 NLM29433682 127922770 ppf: 42 ppct: 7 formats: tig: atl: A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age. aug: au: Perry, N.S.L. Menzies, R. Hodgson, F. Wedgewood, P. Howes, M.-J.R. Brooker, H.J. Wesnes, K.A. Perry, E.K. affil: Dilston Physic Garden, Corbridge, Northumberland, UK sug: subj: Memory Drug Effects Medicine, Herbal Methods Plant Extracts Pharmacodynamics Plant Extracts Research Subjects Middle Age Aged Treatment Outcomes Human Double-Blind Studies Lemon Balm Plants, Medicinal Male Mass Spectrometry Pilot Studies Drugs, Chinese Herbal Pharmacodynamics Female Rosemary Validation Studies Comparative Studies Evaluation Research Multicenter Studies Randomized Controlled Trials Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Objective: To evaluate for the first time the effects of a combination of sage, rosemary and melissa (Salvia officinalis L., Rosmarinus officinalis L. and Melissa officinalis L.; SRM), traditional European medicines, on verbal recall in normal healthy subjects. To devise a suitable study design for assessing the clinical efficacy of traditional herbal medicines for memory and brain function.Methods: Forty-four normal healthy subjects (mean age 61 ± 9.26y SD; m/f 6/38) participated in this study. A double-blind, randomised, placebo-controlled pilot study was performed with subjects randomised into an active and placebo group. The study consisted of a single 2-week term ethanol extract of SRM that was chemically-characterised using high resolution LC-UV-MS/MS analysis. Immediate and delayed word recall were used to assess memory after taking SRM or placebo (ethanol extract of Myrrhis odorata (L.) Scop.). In addition analysis was performed with subjects divided into younger and older subgroups (≤ 62 years mean age n = 26: SRM n = 10, Placebo n = 16; ≥ 63 years n = 19: SRM n = 13, Placebo n = 6).Results: Overall there were no significant differences between treatment and placebo change from baseline for immediate or delayed word recall. However subgroup analysis showed significant improvements to delayed word recall in the under 63 year age group (p < 0.0123) with Cohen's effect size d = 0.92. No adverse effects were observed.Conclusion: This pilot study indicates that an oral preparation of SRM at the selected dose and for the period of administration is more effective than a placebo in supported verbal episodic memory in healthy subjects under 63 years of age. Short- and long- term supplementation with SRM extract merits more robust investigation as an adjunctive treatment for patients with Alzheimer's disease and in the general ageing population. The study design proved a simple cost effective trial protocol to test the efficacy of herbal medicines on verbal episodic memory, with future studies including broader cognitive assessment. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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