Discrimination of Malignant versus Benign Mediastinal Lymph Nodes Using Diffusion MRI with an IVIM Model.
Objectives: To investigate the value of an intravoxel incoherent motion (IVIM) diffusion model for discriminating malignant versus benign mediastinal lymph nodes (MLN).Methods: Thirty-five subjects with enlarged MLN were scanned at 1.5 Tesla. Diffusion-weighted imaging was performed with eight b-val...
| Published in: | European Radiology Vol. 28; no. 3; pp. 1301 - 1310 |
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| Main Authors: | , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Mar2018
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127990348&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127990348 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Mar2018 vid: 28 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 127990348 127990348 NLM28929210 127990348 10.1007/s00330-017-5049-8 NLM28929210 127990348 ppf: 1301 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Discrimination of Malignant versus Benign Mediastinal Lymph Nodes Using Diffusion MRI with an IVIM Model. aug: au: Qi, Li-Ping Yan, Wan-Pu Chen, Ke-Neng Zhong, Zheng Li, Xiao-Ting Cai, Kejia Sun, Ying-Shi Zhou, Xiaohong Joe affil: Department of Radiology, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital and Institute, No. 52 Fu Cheng Rd, Hai Dian District, 100142, Beijing, China sug: subj: Mediastinal Neoplasms Lymph Nodes Pathology Magnetic Resonance Imaging Methods Mediastinum Male Middle Age Aged Neoplasm Metastasis Diagnosis Female ROC Curve Mediastinal Neoplasms Diagnosis Diagnosis, Differential Adult Human Middle Aged: 45-64 years Aged: 65+ years Adult: 19-44 years Male Female ab: Objectives: To investigate the value of an intravoxel incoherent motion (IVIM) diffusion model for discriminating malignant versus benign mediastinal lymph nodes (MLN).Methods: Thirty-five subjects with enlarged MLN were scanned at 1.5 Tesla. Diffusion-weighted imaging was performed with eight b-values. IVIM parameters D, D*, and f, as well as apparent diffusion coefficient (ADC) from a mono-exponential model were obtained. 91 nodes (49 malignant and 42 benign) were analysed with pathologic (n=90) or radiologic (n=1) confirmations. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance.Results: The mean values of D, ADC, and f for the malignant group were significantly lower than those for the benign group (p<0.001), while D* showed no significant difference (p=0.281). In the ROC analysis, the combination of D and f produced the largest area under the curve (0.953) compared to ADC or other individual IVIM parameters, leading to the best specificity (92.9%) and diagnostic accuracy (90.1%).Conclusion: This study demonstrates that the combination of IVIM parameters can improve differentiation between malignant and benign MLN as compared to using ADC alone.Key Points: • Diffusion MRI is useful for non-invasively discriminating malignant versus benign lymph nodes. • A mono-exponential model is not adequate to characterise diffusion process in lymph nodes. • IVIM model is advantageous over mono-exponential model for assessing lymph node malignancy. • Combination of IVIM parameters improves differentiation of malignant versus benign lymph nodes. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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