Differentiation of benign and malignant solid pancreatic masses using magnetic resonance elastography with spin-echo echo planar imaging and three-dimensional inversion reconstruction: a prospective study.
Objectives: To determine the diagnostic performance of MR elastography (MRE) and compare it with serum CA19-9 in differentiating malignant from benign pancreatic masses, with emphasis on differentiating between pancreatic ductal adenocarcinoma (PDAC) and mass-forming pancreatitis (MFP).Methods: We p...
| Publicado en: | European Radiology Vol. 28; no. 3; pp. 936 - 946 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127990360&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127990360 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Mar2018 vid: 28 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 127990360 127990360 NLM28986646 127990360 10.1007/s00330-017-5062-y NLM28986646 127990360 ppf: 936 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Differentiation of benign and malignant solid pancreatic masses using magnetic resonance elastography with spin-echo echo planar imaging and three-dimensional inversion reconstruction: a prospective study. aug: au: Shi, Yu Gao, Feng Li, Yue Tao, Shengzhen Yu, Bing Liu, Zaiyi Liu, Yanqing Glaser, Kevin J. Ehman, Richard L. Guo, Qiyong affil: Department of Radiology, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, 110004, Shenyang, People’s Republic of China sug: subj: Imaging, Three-Dimensional Methods Ultrasonography Methods Magnetic Resonance Imaging Methods Tomography, X-Ray Computed Methods Carcinoma, Ductal Diagnosis Pancreatic Neoplasms Diagnosis Pancreatitis Diagnosis Pancreas Female ROC Curve Aged Prospective Studies Middle Age Male Adult Human Aged: 65+ years Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Objectives: To determine the diagnostic performance of MR elastography (MRE) and compare it with serum CA19-9 in differentiating malignant from benign pancreatic masses, with emphasis on differentiating between pancreatic ductal adenocarcinoma (PDAC) and mass-forming pancreatitis (MFP).Methods: We performed a prospective, consecutive, 24-month study in 85 patients with solid pancreatic masses confirmed by histopathologic examinations. The mass stiffness and stiffness ratio (calculated as the ratio of mass stiffness to the parenchymal stiffness) were assessed. The diagnostic accuracy was analysed by calculating the area under the ROC curve (AUROC).Results: The final diagnosis included 54 malignant tumours (43 patients with PDAC) and 31 benign masses (24 patients with MFP). The stiffness ratio showed better diagnostic performance than the mass stiffness and serum CA19-9 for the differentiation between malignant and benign masses (AUC: 0.912 vs. 0.845 vs. 0.702; P = 0.026, P < 0.001) and, specifically, between PDAC and MFP (AUC: 0.955 vs. 0.882 vs. 0.745; P = 0.026, P = 0.003). The sensitivity, specificity, and accuracy of stiffness ratio for the differentiation of PDAC and MFP were all higher than 0.9.Conclusions: MRE presents an effective and quantitative strategy for non-invasive differentiation between PDAC and MFP based on their mechanical properties.Key Points: • 3D MRE is useful for calculating stiffness of solid pancreatic tumours. • Stiffness ratio outperformed stiffness and CA19-9 for differentiating PDAC from MFP. • Incorporation of 3D MRE into a standard MRI protocol is recommended. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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