Reduced GABA levels correlate with cognitive impairment in patients with relapsing-remitting multiple sclerosis.
Objectives: To investigate if brain gamma-aminobutyric acid (GABA) levels in patients with relapsing-remitting multiple sclerosis (RRMS) are abnormal compared with healthy controls, and their relationship to cognitive function in RRMS.Methods: Twenty-eight RRMS patients and twenty-six healthy contro...
| Publicado en: | European Radiology Vol. 28; no. 3; pp. 1140 - 1149 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=127990361&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 127990361 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Mar2018 vid: 28 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 127990361 127990361 NLM28986640 127990361 10.1007/s00330-017-5064-9 NLM28986640 127990361 ppf: 1140 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Reduced GABA levels correlate with cognitive impairment in patients with relapsing-remitting multiple sclerosis. aug: au: Cao, Guanmei Edden, Richard A. E. Gao, Fei Li, Hao Gong, Tao Chen, Weibo Liu, Xiaohui Wang, Guangbin Zhao, Bin affil: Shandong Medical Imaging Research Institute, Shandong University, 250021, Jinan, Shandong, China sug: subj: Multiple Sclerosis Psychosocial Factors Brain Metabolism GABA Metabolism Case Control Studies Magnetic Resonance Imaging Adult Middle Age Magnetic Resonance Spectroscopy Methods Male Severity of Illness Indices Frontal Lobe Metabolism Limbic System Metabolism Multiple Sclerosis Metabolism Temporal Lobe Metabolism Neuropsychological Tests Female Human Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Objectives: To investigate if brain gamma-aminobutyric acid (GABA) levels in patients with relapsing-remitting multiple sclerosis (RRMS) are abnormal compared with healthy controls, and their relationship to cognitive function in RRMS.Methods: Twenty-eight RRMS patients and twenty-six healthy controls underwent magnetic resonance spectroscopy (MRS) at 3-T to detect GABA signals from posterior cingulate cortex (PCC), medial prefrontal cortex (mPFC) and left hippocampus using the 'MEGAPoint Resolved Spectroscopy Sequence' (MEGA-PRESS) technique. All subjects also underwent a cognitive assessment.Results: In RRMS patients, GABA+ were lower in the PCC (p = 0.036) and left hippocampus (p = 0.039) compared with controls, decreased GABA+ in the PCC and left hippocampus were associated with specific cognitive functions (r = -0.452, p = 0.016 and r = 0.451, p = 0.016 respectively); GABA+ in the mPFC were not significantly decreased or related to any cognitive scores (p > 0.05).Conclusions: This study demonstrates that abnormalities of the GABAergic system may be present in the pathogenesis of RRMS and suggests a potential link between regional GABA levels and cognitive impairment in patients with RRMS.Key Points: • GABA levels may decrease in patients with RRMS. • Lower GABA levels correlated with worse cognitive performance in patients with RRMS. • Dysfunctional GABAergic neurotransmission may have a role in cognitive impairment in RRMS. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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