Attention and processing speed performance in multiple sclerosis is mostly related to thalamic volume.
Cognitive impairment (CI), mainly involving attention and processing speed (A-PS), is a common and disabling symptom in multiple sclerosis (MS). Symbol Digit Modalities Test (SDMT) is one of the more sensitive and reliable tests to assess A-PS deficits in MS. Structural MRI correlates of A-PS in MS...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 1; pp. 20 - 29 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128033922&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128033922 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2018 vid: 12 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128033922 128033922 NLM28083844 10.1007/s11682-016-9667-6 NLM28083844 128033922 ppf: 20 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Attention and processing speed performance in multiple sclerosis is mostly related to thalamic volume. aug: au: Bisecco, Alvino Stamenova, Svetlana Caiazzo, Giuseppina d’Ambrosio, Alessandro Sacco, Rosaria Docimo, Renato Esposito, Sabrina Cirillo, Mario Esposito, Fabrizio Bonavita, Simona Tedeschi, Gioacchino Gallo, Antonio d'Ambrosio, Alessandro affil: I Division of Neurology, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania “Luigi Vanvitelli”, piazza Miraglia, 2, 80138, Naples, Italy sug: subj: Attention Mental Processes Thalamus Multiple Sclerosis Multiple Sclerosis Psychosocial Factors Thalamus Pathology Linear Regression Gray Matter Pathology Basal Ganglia Magnetic Resonance Imaging Neuropsychological Tests Basal Ganglia Pathology Atrophy Imaging, Three-Dimensional Body Weights and Measures Female Cerebellum Pathology Male Adult Cerebellum Gray Matter Multiple Sclerosis Pathology Adult: 19-44 years Female Male ab: Cognitive impairment (CI), mainly involving attention and processing speed (A-PS), is a common and disabling symptom in multiple sclerosis (MS). Symbol Digit Modalities Test (SDMT) is one of the more sensitive and reliable tests to assess A-PS deficits in MS. Structural MRI correlates of A-PS in MS still need to be clarified. This study aimed to investigate, in a large group of MS patients, the relationship between regional gray matter (GM) atrophy and SDMT performance. 125 relapsing remitting MS patients and 52 healthy controls (HC) underwent a 3 T-MRI protocol including high-resolution 3D-T1 imaging. All subjects underwent a neurological evaluation and SDMT. A Voxel Based Morphometry analysis was performed to assess: 1) correlations between regional GM volume and SDMT performance in MS patients; 2) regional differences in GM volume between MS patients and HC. Thalamic, putamen and cerebellar volumes were also calculated using FIRST tool from the FMRIB Software Library. A linear regression analysis was performed to assess the contribution of each one of these structures to A-PS performance. A significant negative correlation was found between regional GM volume and SDMT score at the level of the thalamus, cerebellum, putamen, and occipital cortex in MS patients. Thalamus, cerebellum and putamen also showed significant GM atrophy in MS patients compared to HC. Thalamic atrophy is also an independent and additional contributor to A-PS deficits in MS patients. These findings support the role of thalamus as the most relevant GM structure subtending A-PS performance in MS, as measured by SDMT. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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