Relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury.
This study aims to (1) investigate the neuropathology of mild to severe pediatric TBI and (2) elucidate the predictive value of conventional and innovative neuroimaging for functional outcome. Children aged 8-14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI a...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 1; pp. 29 - 44 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128033928&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128033928 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2018 vid: 12 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128033928 128033928 NLM28092022 128033928 10.1007/s11682-017-9673-3 NLM28092022 128033928 ppf: 29 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury. aug: au: Königs, Marsh Pouwels, Petra JW Ernest van Heurn, LW Bakx, Roel Jeroen Vermeulen, R Carel Goslings, J Poll-The, Bwee Tien van der Wees, Marleen Catsman-Berrevoets, Coriene E Oosterlaan, Jaap Ernest van Heurn, L W Goslings, J Carel affil: Clinical Neuropsychology Section, FGB VU University Amsterdam, Van der Boechorststraat 1, 1081BT, Amsterdam, The Netherlands sug: subj: Adolescent Behavior Cognition Child Behavior Brain Magnetic Resonance Imaging Prognosis Mental Disorders Female Adolescence Child Cross Sectional Studies Child Behavior Disorders Etiology Learning Disorders Etiology Neuroradiography Prospective Studies Child Behavior Disorders Mental Disorders Etiology Male Learning Disorders Human Tomography, X-Ray Computed Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adolescent: 13-18 years Child: 6-12 years Female Male ab: This study aims to (1) investigate the neuropathology of mild to severe pediatric TBI and (2) elucidate the predictive value of conventional and innovative neuroimaging for functional outcome. Children aged 8-14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI and risk factors for complicated TBI (mildRF+, n = 20) or moderate/severe TBI (n = 17) at 2.8 years post-injury. Neuroimaging measures included: acute computed tomography (CT), volumetric analysis on post-acute conventional T1-weighted magnetic resonance imaging (MRI) and post-acute diffusion tensor imaging (DTI, analyzed using tract-based spatial statistics and voxel-wise regression). Functional outcome was measured using Common Data Elements for neurocognitive and behavioral functioning. The results show that intracranial pathology on acute CT-scans was more prevalent after moderate/severe TBI (65%) than after mildRF+ TBI (35%; p = .035), while both groups had decreased white matter volume on conventional MRI (ps ≤ .029, ds ≥ -0.74). The moderate/severe TBI group further showed decreased fractional anisotropy (FA) in a widespread cluster affecting all white matter tracts, in which regional associations with neurocognitive functioning were observed (FSIQ, Digit Span and RAVLT Encoding) that consistently involved the corpus callosum. FA had superior predictive value for functional outcome (i.e. intelligence, attention and working memory, encoding in verbal memory and internalizing problems) relative to acute CT-scanning (i.e. internalizing problems) and conventional MRI (no predictive value). We conclude that children with mildRF+ TBI and moderate/severe TBI are at risk of persistent white matter abnormality. Furthermore, DTI has superior predictive value for neurocognitive out-come relative to conventional neuroimaging. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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