In vivo neuroimaging and behavioral correlates in a rat model of chemotherapy-induced cognitive dysfunction.
Adjuvant chemotherapy has been used for decades to treat cancer, and it is well known that disruptions in cognitive function and memory are common chemotherapeutic adverse effects. However, studies using neuropsychological metrics have also reported group differences in cognitive function and memory...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 1; pp. 87 - 96 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128033929&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128033929 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2018 vid: 12 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128033929 128033929 NLM28108946 128033929 10.1007/s11682-017-9674-2 NLM28108946 128033929 ppf: 87 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: In vivo neuroimaging and behavioral correlates in a rat model of chemotherapy-induced cognitive dysfunction. aug: au: Barry, Robert L. Byun, Nellie E. Tantawy, M. Noor Mackey, Chase A. Wilson, George H. Stark, Adam J. Flom, Michael P. Gee, Laura C. Quarles, C. Chad Wilson, George H 3rd affil: Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA sug: subj: Brain Drug Effects Antineoplastic Agents Doxorubicin Brain Models, Biological Animal Studies Magnetic Resonance Imaging Radiopharmaceuticals Female Tomography, Emission-Computed Tomography, X-Ray Computed Brain Mapping Rats Fludeoxyglucose F 18 Conditioning (Psychology) Drug Effects Neuroradiography Recognition (Psychology) Drug Effects Fear Drug Effects Validation Studies Comparative Studies Evaluation Research Multicenter Studies Female ab: Adjuvant chemotherapy has been used for decades to treat cancer, and it is well known that disruptions in cognitive function and memory are common chemotherapeutic adverse effects. However, studies using neuropsychological metrics have also reported group differences in cognitive function and memory before or without chemotherapy, suggesting that complex factors obscure the true etiology of chemotherapy-induced cognitive dysfunction (CICD) in humans. Therefore, to better understand possible mechanisms of CICD, we explored the effects of CICD in rats through cognition testing using novel object recognition (NOR) and contextual fear conditioning (CFC), and through metabolic neuroimaging via [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET). Cancer-naïve, female Sprague-Dawley rats were administered either saline (1 mL/kg) or doxorubicin (DOX) (1 mg/kg in a volume of 1 mL/kg) weekly for five weeks (total dose = 5 mg/kg), and underwent cognition testing and PET imaging immediately following the treatment regime and 30 days post treatment. We did not observe significant differences with CFC testing post-treatment for either group. However, the chemotherapy group exhibited significantly decreased performance in the NOR test and decreased 18F-FDG uptake only in the prefrontal cortex 30 days post-treatment. These results suggest that long-term impairment within the prefrontal cortex is a plausible mechanism of CICD in this study, suggesting DOX-induced toxicity in the prefrontal cortex at the dose used. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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