Brain white matter structural networks in patients with non-neuropsychiatric systemic lupus erythematosus.
Previous neuroimaging studies have revealed cognitive dysfunction in patients with systemic lupus erythematosus (SLE) and suggested that it may be related to disrupted brain white matter (WM) connectivity. However, no study has examined the topological properties of brain WM structural networks in S...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 1; pp. 142 - 156 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128033935&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128033935 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2018 vid: 12 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128033935 128033935 NLM28190161 128033935 10.1007/s11682-017-9681-3 NLM28190161 128033935 ppf: 142 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Brain white matter structural networks in patients with non-neuropsychiatric systemic lupus erythematosus. aug: au: Zhao, Ling Tan, Xiangliang Wang, Junjing Han, Kai Niu, Meiqi Xu, Jun Liu, Xiaojin Zhao, Xixi Zhong, Miao Huang, Qin Xu, Yikai Huang, Ruiwang affil: Center for the Study of Applied Psychology, School of Psychology, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, Brain Study Institute, South China Normal University, 510631, Guangzhou, People’s Republic of China sug: subj: Brain Lupus Erythematosus, Systemic Human Magnetic Resonance Imaging Female Brain Pathology Middle Age Lupus Erythematosus, Systemic Pathology Adolescence Neural Pathways Adult Neural Pathways Pathology Young Adult Validation Studies Comparative Studies Evaluation Research Multicenter Studies Language Tests Scales Middle Aged: 45-64 years Adolescent: 13-18 years Adult: 19-44 years Female ab: Previous neuroimaging studies have revealed cognitive dysfunction in patients with systemic lupus erythematosus (SLE) and suggested that it may be related to disrupted brain white matter (WM) connectivity. However, no study has examined the topological properties of brain WM structural networks in SLE patients, especially in patients with non-neuropsychiatric SLE (non-NPSLE). In this study, we acquired DTI datasets from 28 non-NPSLE patients and 24 healthy controls, constructed their brain WM structural networks by using a deterministic fiber tracking approach, estimated the topological parameters of their structural networks, and compared their group differences. We reached the following results: 1) At the global level, the non-NPSLE patients showed significantly increased characteristic path length, normalized clustering coefficient and small-worldness, but significantly decreased global efficiency and local efficiency compared to the controls; 2) At the nodal level, the non-NPSLE patients had significantly decreased nodal efficiency in regions related to movement control, executive control, and working memory (bilateral precentral gyri, bilateral middle frontal gyri, bilateral inferior parietal lobes, left median cingulate gyrus and paracingulate gyrus, and right middle temporal gyrus). In addition, to pinpointing the injured WM fiber tracts in the non-NPSLE patients, we reconstructed the major brain WM pathways connecting the abnormal regions at the nodal level with the corticospinal tract (CST), superior longitudinal fasciculus-parietal terminations (SLFP), and superior longitudinal fasciculus-temporal terminations (SLFT). By analyzing the diffusion parameters along these WM fiber pathways, we detected abnormal diffusion parameters in the bilateral CST and right SLFT in the non-NPSLE patients. These results seem to indicate that injured brain WM connectivity exists in SLE patients even in the absence of neuropsychiatric symptoms. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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