Effectiveness of topical green tea against multidrug-resistant in cases of primary pyoderma: An open controlled trial.
Background: Antimicrobial activity of green tea against Staphylococcus aureus both in vitro and in vivo has been reported recently. Studies on clinical efficacy and safety of green tea as antibacterial agent against S. aureus in human cases are rare.Objectives: To evaluate the clinical effectiveness...
| Publicado en: | Indian Journal of Dermatology, Venereology & Leprology Vol. 84; no. 2; pp. 163 - 169 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Scientific Scholar LLC
Mar/Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128069751&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128069751 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03786323 SV4 jtl: Indian Journal of Dermatology, Venereology & Leprology issn: 03786323 maglogo: N pubinfo: dt: Mar/Apr2018 vid: 84 iid: 2 pid: 56013 pub: Scientific Scholar LLC place: Pittsford, New York artinfo: ui: 128069751 128069751 NLM29146890 128069751 10.4103/ijdvl.IJDVL_207_16 NLM29146890 128069751 ppf: 163 ppct: 6 formats: tig: atl: Effectiveness of topical green tea against multidrug-resistant in cases of primary pyoderma: An open controlled trial. aug: au: Umashankar, Nagaraju Pemmanda, Belliappa Gopkumar, P Hemalatha, A Sundar, Priya Prashanth, H Hemalatha, A J Sundar, Priya K Prashanth, H V affil: Department of Dermatology, Rajarajeswari Medical College and Hospital, Bengaluru sug: subj: Plant Extracts Administration and Dosage Staphylococcus Aureus Drug Effects Drug Resistance, Microbial Drug Effects Staphylococcal Infections Drug Therapy Pyoderma Drug Therapy Tea Adolescence Staphylococcus Aureus Physiology Pyoderma Diagnosis Prospective Studies Staphylococcus Aureus Male Female Treatment Outcomes Cross Sectional Studies Administration, Topical Child Drug Resistance, Microbial Physiology Staphylococcal Infections Diagnosis Human Validation Studies Comparative Studies Evaluation Research Multicenter Studies Randomized Controlled Trials Adolescent: 13-18 years Child: 6-12 years Male Female ab: Background: Antimicrobial activity of green tea against Staphylococcus aureus both in vitro and in vivo has been reported recently. Studies on clinical efficacy and safety of green tea as antibacterial agent against S. aureus in human cases are rare.Objectives: To evaluate the clinical effectiveness and safety of topical green tea on primary pyoderma caused by S. aureus. We also attempted to determine the minimum inhibitory concentration of green tea against S. aureus and methicillin-resistant S. aureus.Methods: Open label, prospective, placebo-controlled study included community-acquired primary pyoderma cases caused by S. aureus. Severity grading was done on a scale of 1-5. Green tea ointment 3% and placebo ointment were used. Cure was defined on the basis of negative culture and assessment of clinical improvement. Minimum inhibitory concentration was determined by agar dilution method. Data were analyzed using Statistical Package for Social Sciences (SPSS) software version 16.Results: Of the 372 patients, 250 received green tea and 122 received placebo. Multidrug-resistant S. aureus was isolated in 89.1% in green tea group and 81.1% in placebo group, respectively. Methicillin-resistant S. aureus was isolated in 24 patients. Cure was seen in 86% in green tea group and 6.6% in placebo group which was statistically very significant. The number of days for comprehensive cure in green tea group was 9.2 ± 6.4 days. All patients with methicillin-resistant S. aureus infection in the green tea group were cured. Minimum inhibitory concentration of green tea against S. aureus was 0.0265 ± 0.008 μg/ml and against methicillin-resistant S. aureus was 0.0205 ± 0.003 μg/ml.Limitations Of the Study: Comparative trial was not conducted in the same patient with different lesions; children less than seven years were not considered as the school authorities did not permit for younger children to be included in the study and true randomization and blinding of investigators were not done.Conclusions: Green tea has a significant antibacterial effect against multidrug-resistant S. aureus. Minimum inhibitory concentration of green tea is established and is promising in methicillin-resistant S. aureus infections. pubtype: Academic Journal doctype: pictorial research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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